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10.1371/journal.pone.0121939 http://scihub22266oqcxt.onion/10.1371/journal.pone.0121939 C4379100!4379100!25822822     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (3): ä Nephropedia Template TP {{tp|p=25822822|t=2015. Pyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice |pdf=|usr=}}{{25822822}} gab.com Text Pyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25822822 #FOAvip Liver fibrosis represents the consequences of a sustained wound healing response to chronic liver injuries, and its progression toward cirrhosis is the major cause of liver-related morbidity and mortality worldwide. However, anti-fibrotic treatment remains an unconquered area for drug development. Accumulating evidence indicate that oxidative stress plays a critical role in liver fibrogenesis. In this study, we found that PQQ, a natural anti-oxidant present in a wide variety of human foods, exerted potent anti-fibrotic and ROS-scavenging activity in Balb/C mouse models of liver fibrosis. The antioxidant activity of PQQ was involved in the modulation of multiple steps during liver fibrogenesis, including chronic liver injury, hepatic inflammation, as well as activation of hepatic stellate cells and production of extracellular matrix. PQQ also suppressed the up-regulation of RACK1 in activated HSCs in vivo and in vitro. Our data suggest that PQQ suppresses oxidative stress and liver fibrogenesis in mice, and provide rationale for the clinical application of PQQ in the prevention and treatment of liver fibrosis. Twit Text FOAVip Pyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25822822 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25822822 #FOAvip English Wikipedia <ref>{{Cite pmid|25822822}}</ref> Pyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice #MMPMID25822822 Jia D; Duan F; Peng P; Sun L; Ruan Y; Gu J PLoS One 2015[]; 10 (3): ä PMID25822822show ga Liver fibrosis represents the consequences of a sustained wound healing response to chronic liver injuries, and its progression toward cirrhosis is the major cause of liver-related morbidity and mortality worldwide. However, anti-fibrotic treatment remains an unconquered area for drug development. Accumulating evidence indicate that oxidative stress plays a critical role in liver fibrogenesis. In this study, we found that PQQ, a natural anti-oxidant present in a wide variety of human foods, exerted potent anti-fibrotic and ROS-scavenging activity in Balb/C mouse models of liver fibrosis. The antioxidant activity of PQQ was involved in the modulation of multiple steps during liver fibrogenesis, including chronic liver injury, hepatic inflammation, as well as activation of hepatic stellate cells and production of extracellular matrix. PQQ also suppressed the up-regulation of RACK1 in activated HSCs in vivo and in vitro. Our data suggest that PQQ suppresses oxidative stress and liver fibrogenesis in mice, and provide rationale for the clinical application of PQQ in the prevention and treatment of liver fibrosis. äPyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice (epmc).pdf DeepDyve Pubget Overpricing