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10.1371/journal.pone.0121720 http://scihub22266oqcxt.onion/10.1371/journal.pone.0121720 C4379087!4379087 !25821967     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25821967 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (3 ): e0121720 Nephropedia Template TP {{tp|p=25821967 |t=2015. Sustained endothelial expression of HoxA5 in vivo impairs pathological angiogenesis and tumor progression |pdf=|usr=}}{{25821967 }} gab.com Text Sustained endothelial expression of HoxA5 in vivo impairs pathological angiogenesis and tumor progression JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25821967 #FOAvip HoxA5 is expressed in quiescent endothelial cells (EC), but absent in activated angiogenic EC. To examine the efficacy of targeting HoxA5 therapeutically to quell pathologic or tumor angiogenesis, we generated an inducible, transgenic mouse model of sustained HoxA5 expression in ECs. During pathologic angiogenesis, sustained HoxA5 regulates expression several angiogenic effector molecules, notably increased expression of TSP-2 and reduced expression of VEGF, thus leading to inhibition of pathological angiogenesis in tissues. To evaluate if this impressive reduction of vascularization could also impact tumor angiogenesis, HoxA5 mice were bred with a mouse model of de novo squamous carcinogenesis, e.g., K14-HPV16 mice. Activation of EC-HoxA5 significantly reduced infiltration by mast cells into neoplastic skin, an early hallmark of progression to dysplasia, reduced angiogenic vasculature, and blunted characteristics of tumor progression. To evaluate HoxA5 as a therapeutic, topical application of a HoxA5 transgene onto early neoplastic skin of K14-HPV16 mice similarly resulted in a significant impairment of angiogenic vasculature and progression to dysplasia to a similar extent as observed with genetic delivery of HoxA5. Together these data indicate that HoxA5 represents a novel molecule for restricting pathological and tumorigenic angiogenesis. Twit Text FOAVip Sustained endothelial expression of HoxA5 in vivo impairs pathological angiogenesis and tumor progression ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25821967 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25821967 #FOAvip English Wikipedia <ref>{{Cite pmid|25821967 }}</ref> Sustained endothelial expression of HoxA5 in vivo impairs pathological angiogenesis and tumor progression #MMPMID25821967 Cuevas I ; Layman H ; Coussens L ; Boudreau N PLoS One 2015[]; 10 (3 ): e0121720 PMID25821967 show ga HoxA5 is expressed in quiescent endothelial cells (EC), but absent in activated angiogenic EC. To examine the efficacy of targeting HoxA5 therapeutically to quell pathologic or tumor angiogenesis, we generated an inducible, transgenic mouse model of sustained HoxA5 expression in ECs. During pathologic angiogenesis, sustained HoxA5 regulates expression several angiogenic effector molecules, notably increased expression of TSP-2 and reduced expression of VEGF, thus leading to inhibition of pathological angiogenesis in tissues. To evaluate if this impressive reduction of vascularization could also impact tumor angiogenesis, HoxA5 mice were bred with a mouse model of de novo squamous carcinogenesis, e.g., K14-HPV16 mice. Activation of EC-HoxA5 significantly reduced infiltration by mast cells into neoplastic skin, an early hallmark of progression to dysplasia, reduced angiogenic vasculature, and blunted characteristics of tumor progression. To evaluate HoxA5 as a therapeutic, topical application of a HoxA5 transgene onto early neoplastic skin of K14-HPV16 mice similarly resulted in a significant impairment of angiogenic vasculature and progression to dysplasia to a similar extent as observed with genetic delivery of HoxA5. Together these data indicate that HoxA5 represents a novel molecule for restricting pathological and tumorigenic angiogenesis. |Animals [MESH] |Carcinogenesis/genetics/pathology [MESH] |Disease Progression [MESH] |Endothelial Cells/*metabolism/*pathology/virology [MESH] |Homeodomain Proteins/*genetics [MESH] |Human papillomavirus 16 [MESH] |Mice [MESH] |Mice, Transgenic/genetics [MESH] |Neoplastic Processes [MESH] |Neovascularization, Pathologic/*genetics/pathology [MESH] |Papillomavirus Infections/genetics/pathology [MESH] |Phosphoproteins/*genetics [MESH] |Precancerous Conditions/genetics/pathology/virology [MESH] |Skin Neoplasms/*genetics/*pathology/virology [MESH] |Thrombospondins/genetics [MESH] |Transcription Factors [MESH] |Transgenes/genetics [MESH]Sustained endothelial expression of HoxA5 in vivo impairs pathological(epmc).pdf DeepDyve Pubget Overpricing