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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Gastroenterol+Res+Pract
2015 ; 2015
(ä): 567920
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Myoxinol (Hydrolyzed Hibiscus esculentus Extract) in the Cure of Chronic Anal
Fissure: Early Clinical and Functional Outcomes
#MMPMID25861259
Renzi A
; Brillantino A
; Di Sarno G
; D'Aniello F
; Ziccardi S
; Paladino F
; Iacobellis F
Gastroenterol Res Pract
2015[]; 2015
(ä): 567920
PMID25861259
show ga
Objective. This study was designed to evaluate the early results of the topical
application of Hydrolyzed Hibiscus esculentus Extract 3% ointment (Myoxinol 3%),
a novel local product with Botox-like activity, in the conservative treatment of
chronic anal fissure (CAF). Methods. Among all patients with CAF observed during
the study period, 31 subjects met the inclusion criteria and underwent medical
therapy with Myoxinol 3% ointment every 12 hours for 6 weeks. Two patients were
lost to follow-up. Clinical and manometric follow-up was carried out eight weeks
after treatment. Results. At follow-up the success rate was 72.4% (21/29); median
VAS score and mean anal resting pressure were significantly lower if compared
with respective baseline data. The only one adverse effect of the topical
application of Myoxinol 3% ointment was perianal itch, which was reported by 3,4%
(1/29) of the patients available for the analysis. However, in this case this
symptom did not cause interruption of the treatment. Conclusions. The topical
application of Myoxinol 3% ointment in the cure of CAF shows encouraging early
results. Further researches with a larger series and a longer follow-up are
needed to confirm these data.