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10.1073/pnas.1421917112 http://scihub22266oqcxt.onion/10.1073/pnas.1421917112 C4378418!4378418!25775519     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (12): 3764-9 Nephropedia Template TP {{tp|p=25775519|t=2015. Environmental stress induces trinucleotide repeat mutagenesis in human cells |pdf=|usr=}}{{25775519}} gab.com Text Environmental stress induces trinucleotide repeat mutagenesis in human cells JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25775519 #FOAvip Environmental stress induces complex cellular responses that improve the odds of survival. One effect of the cellular stress response is to relax the fidelity of DNA repair, with the counterintuitive strategy of increasing mutagenesis to improve fitness. Because microsatellite repeats, which are intrinsically highly mutable, serve as tuning knobs for evolutionary change, we asked whether environmental stress increased their mutagenesis. We found that cold, heat, hypoxic, and oxidative stresses induce trinucleotide repeat (TNR) mutagenesis, in a way that depends on stress response factors and apparently involves DNA rereplication. Because TNRs are overrepresented in gene-regulatory proteins, stress-induced TNR mutagenesis may provide a path for the environment to subtly alter gene regulatory networks?with attendant changes in cell behavior?during development, disease, and evolution. Twit Text FOAVip Environmental stress induces trinucleotide repeat mutagenesis in human cells ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25775519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25775519 #FOAvip English Wikipedia <ref>{{Cite pmid|25775519}}</ref> Environmental stress induces trinucleotide repeat mutagenesis in human cells #MMPMID25775519 Chatterjee N; Lin Y; Santillan BA; Yotnda P; Wilson JH Proc Natl Acad Sci U S A 2015[Mar]; 112 (12): 3764-9 PMID25775519show ga Environmental stress induces complex cellular responses that improve the odds of survival. One effect of the cellular stress response is to relax the fidelity of DNA repair, with the counterintuitive strategy of increasing mutagenesis to improve fitness. Because microsatellite repeats, which are intrinsically highly mutable, serve as tuning knobs for evolutionary change, we asked whether environmental stress increased their mutagenesis. We found that cold, heat, hypoxic, and oxidative stresses induce trinucleotide repeat (TNR) mutagenesis, in a way that depends on stress response factors and apparently involves DNA rereplication. Because TNRs are overrepresented in gene-regulatory proteins, stress-induced TNR mutagenesis may provide a path for the environment to subtly alter gene regulatory networks?with attendant changes in cell behavior?during development, disease, and evolution. äEnvironmental stress induces trinucleotide repeat mutagenesis in human(epmc).pdf DeepDyve Pubget Overpricing