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10.1101/gad.254631.114

http://scihub22266oqcxt.onion/10.1101/gad.254631.114
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C4378194!4378194!25762440
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suck abstract from ncbi


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pmid25762440      Genes+Dev 2015 ; 29 (6): 617-29
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  • The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing #MMPMID25762440
  • Vourekas A; Zheng K; Fu Q; Maragkakis M; Alexiou P; Ma J; Pillai RS; Mourelatos Z; Wang PJ
  • Genes Dev 2015[Mar]; 29 (6): 617-29 PMID25762440show ga
  • Piwi-piRNA ribonucleoproteins (piRNPs) enforce retrotransposon silencing, a function critical for preserving genome integrity of germ cells. Vourekas et al. found that MOV10L1 exhibits 5? to 3? directional RNA unwinding activity in vitro and that a point mutation that abolishes this activity causes a failure in primary piRNA biogenesis in vivo. MOV10L1 selectively binds piRNA precursor transcripts and is essential for the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins.
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