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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Bioeng+Biotechnol 2015 ; 3 (ä): ä Nephropedia Template TP
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A Review of Cellularization Strategies for Tissue Engineering of Whole Organs #MMPMID25870857
Scarritt ME; Pashos NC; Bunnell BA
Front Bioeng Biotechnol 2015[]; 3 (ä): ä PMID25870857show ga
With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for organ engineering were generated from numerous tissues, including the heart, lung, liver, kidney, and pancreas, for use as alternatives to traditional organ transplantation. Biomedical researchers now face the challenge of adequately and efficiently recellularizing these organ scaffolds. Herein, an overview of whole organ decellularization and a thorough review of the current literature for whole organ recellularization are presented. The cell types, delivery methods, and bioreactors employed for recellularization are discussed along with commercial and clinical considerations, such as immunogenicity, biocompatibility, and Food and Drug Administartion regulation.