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10.1038/ncomms7576 http://scihub22266oqcxt.onion/10.1038/ncomms7576 C4377839!4377839!25807892     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): 6576 Nephropedia Template TP {{tp|p=25807892|t=2015. EphrinB2 controls vessel pruning through STAT1-JNK3 signaling |pdf=|usr=}}{{25807892}} gab.com Text EphrinB2 controls vessel pruning through STAT1-JNK3 signaling JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25807892 #FOAvip Angiogenesis produces primitive vascular networks that need pruning to yield hierarchically organized and functional vessels. Despite the critical importance of vessel pruning to vessel patterning and function, the mechanisms regulating this process are not clear. Here we show that EphrinB2, a well-known player in angiogenesis, is an essential regulator of endothelial cell death and vessel pruning. This regulation depends upon phosphotyrosine-EphrinB2 signaling repressing JNK3 activity via STAT1. JNK3 activation causes endothelial cell death. In the absence of JNK3, hyaloid vessel physiological pruning is impaired, associated with abnormal persistence of hyaloid vessels, defective retinal vasculature and microphthalmia. This syndrome closely resembles human persistent hyperplastic primary vitreus (PHPV), attributed to failed involution of hyaloid vessels. Our results provide evidence that EphrinB2/STAT1/JNK3 signaling is essential for vessel pruning, and that defects in this pathway may contribute to PHPV. Twit Text FOAVip EphrinB2 controls vessel pruning through STAT1-JNK3 signaling ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25807892 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25807892 #FOAvip English Wikipedia <ref>{{Cite pmid|25807892}}</ref> EphrinB2 controls vessel pruning through STAT1-JNK3 signaling #MMPMID25807892 Salvucci O; Ohnuki H; Maric D; Hou X; Li X; Yoon SO; Segarra M; Eberhart CG; Acker-Palmer A; Tosato G Nat Commun 2015[]; 6 (ä): 6576 PMID25807892show ga Angiogenesis produces primitive vascular networks that need pruning to yield hierarchically organized and functional vessels. Despite the critical importance of vessel pruning to vessel patterning and function, the mechanisms regulating this process are not clear. Here we show that EphrinB2, a well-known player in angiogenesis, is an essential regulator of endothelial cell death and vessel pruning. This regulation depends upon phosphotyrosine-EphrinB2 signaling repressing JNK3 activity via STAT1. JNK3 activation causes endothelial cell death. In the absence of JNK3, hyaloid vessel physiological pruning is impaired, associated with abnormal persistence of hyaloid vessels, defective retinal vasculature and microphthalmia. This syndrome closely resembles human persistent hyperplastic primary vitreus (PHPV), attributed to failed involution of hyaloid vessels. Our results provide evidence that EphrinB2/STAT1/JNK3 signaling is essential for vessel pruning, and that defects in this pathway may contribute to PHPV. äEphrinB2 controls vessel pruning through STAT1-JNK3 signaling (epmc).pdf DeepDyve Pubget Overpricing