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10.1038/ncomms7604 http://scihub22266oqcxt.onion/10.1038/ncomms7604 C4377644!4377644!25790293     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun ä ; 6 (ä): ä Nephropedia Template TP {{tp|p=25790293|t=ä. Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia |pdf=|usr=}}{{25790293}} gab.com Text Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25790293 #FOAvip There is incomplete understanding of genetic heterogeneity and clonal evolution during cancer progression. Here we use deep whole-exome sequencing to describe the clonal architecture and evolution of 20 pediatric B-acute lymphoblastic leukaemias from diagnosis to relapse. We show that clonal diversity is comparable at diagnosis and relapse and clonal survival from diagnosis to relapse is not associated with mutation burden. Six pathways were frequently mutated, with NT5C2, CREBBP, WHSC1, TP53, USH2A, NRAS and IKZF1 mutations enriched at relapse. Half of the leukaemias had multiple subclonal mutations in a pathway or gene at diagnosis, but mostly with only one, usually minor clone, surviving therapy to acquire additional mutations and become the relapse founder clone. Relapse-specific mutations in NT5C2 were found in nine cases, with mutations in four cases being in descendants of the relapse founder clone. These results provide important insights into the genetic basis of treatment failure in ALL and have implications for the early detection of mutations driving relapse. Twit Text FOAVip Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25790293 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25790293 #FOAvip English Wikipedia <ref>{{Cite pmid|25790293}}</ref> Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia #MMPMID25790293 Ma X; Edmonson M; Yergeau D; Muzny DM; Hampton OA; Rusch M; Song G; Easton J; Harvey RC; Wheeler DA; Ma J; Doddapaneni H; Vadodaria B; Wu G; Nagahawatte P; Carroll WL; Chen IM; Gastier-Foster JM; Relling MV; Smith MA; Devidas M; Auvil JMG; Downing JR; Loh ML; Willman CL; Gerhard DS; Mullighan CG; Hunger SP; Zhang J Nat Commun ä[]; 6 (ä): ä PMID25790293show ga There is incomplete understanding of genetic heterogeneity and clonal evolution during cancer progression. Here we use deep whole-exome sequencing to describe the clonal architecture and evolution of 20 pediatric B-acute lymphoblastic leukaemias from diagnosis to relapse. We show that clonal diversity is comparable at diagnosis and relapse and clonal survival from diagnosis to relapse is not associated with mutation burden. Six pathways were frequently mutated, with NT5C2, CREBBP, WHSC1, TP53, USH2A, NRAS and IKZF1 mutations enriched at relapse. Half of the leukaemias had multiple subclonal mutations in a pathway or gene at diagnosis, but mostly with only one, usually minor clone, surviving therapy to acquire additional mutations and become the relapse founder clone. Relapse-specific mutations in NT5C2 were found in nine cases, with mutations in four cases being in descendants of the relapse founder clone. These results provide important insights into the genetic basis of treatment failure in ALL and have implications for the early detection of mutations driving relapse. äRise and fall of subclones from diagnosis to relapse in pediatric B-ac(epmc).pdf DeepDyve Pubget Overpricing