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PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced
the anti-tumor activity of Sorafenib by changing the tumor microenvironment
#MMPMID25819872
Lam W
; Jiang Z
; Guan F
; Huang X
; Hu R
; Wang J
; Bussom S
; Liu SH
; Zhao H
; Yen Y
; Cheng YC
Sci Rep
2015[Mar]; 5
(?): 9384
PMID25819872
show ga
PHY906 (KD018) is a four-herb Chinese Medicine Formula. It has been shown to
potentially enhance the therapeutic indices of different class anticancer agents
in vivo. Here, PHY906 is reported to enhance the anti-tumor activity of Sorafenib
in nude mice bearing HepG2 xenografts. Among the four herbal ingredients of
PHY906, Scutellaria baicalensis Georgi (S) and Paeonia lactiflora Pall (P) are
required; however, S plays a more important role than P in increasing tumor
apoptosis induced by Sorafenib with an increase of mouse(m)FasL and human(h)FasR
expression. PHY906 may potentiate Sorafenib action by increasing hMCP1 expression
and enhancing infiltration of macrophages into tumors with a higher M1/M2 (tumor
rejection) signature expression pattern, as well as affect autophagy by
increasing AMPK?-P and ULK1-S555-P of tumors. Depletion of macrophage could
counteract PHY906 to potentiate the anti-tumor activity of Sorafenib. It was
reported that tumor cells with higher levels of ERK1/2-P are more susceptible to
Sorafenib, and the S component of PHY906 may increase ERK1/2-P via inhibition of
ERK1/2 phosphatase in HepG2 tumors. PHY906 may potentiate the anti-hepatoma
activity of Sorafenib by multiple mechanisms targeting on the inflammatory state
of microenvironment of tumor tissue through two major ingredients (P and S) of
PHY906.
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