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Nitrooleic Acid Attenuates Lipid Metabolic Disorders and Liver Steatosis in
DOCA-Salt Hypertensive Mice
#MMPMID25861250
Wang H
; Sun J
; Jia Z
; Yang T
; Xu L
; Zhao B
; Yu K
; Wang R
PPAR Res
2015[]; 2015
(?): 480348
PMID25861250
show ga
Nitrooleic acid (OA-NO2) is endogenous ligands for peroxisome
proliferator-activated receptors. The present study was aimed at investigating
the beneficial effects of OA-NO2 on the lipid metabolism and liver steatosis in
deoxycorticosterone acetate- (DOCA-) salt induced hypertensive mice model. Male
C57BL/6 mice were divided to receive DOCA-salt plus OA-NO2 or DOCA-salt plus
vehicle and another group received neither DOCA-salt nor OA-NO2 (control group).
After 3-week treatment with DOCA-salt plus 1% sodium chloride in drinking fluid,
the hypertension was noted; however, OA-NO2 had no effect on the hypertension. In
DOCA-salt treated mice, the plasma triglyceride and total cholesterol levels were
significantly increased compared to control mice, and pretreatment with OA-NO2
significantly reduced these parameters. Further, the histopathology of liver
exhibited more lipid distribution together with more serious micro- and
macrovesicular steatosis after DOCA-salt treatment and that was consistent with
liver tissue triglyceride and nonesterified fatty acids (NEFA) content. The mice
pretreated with OA-NO2 showed reduced liver damage accompanied with low liver
lipid content. Moreover, the liver TBARS, together with the expressions of
gp91phox and p47phox, were parallelly decreased. These findings indicated that
OA-NO2 had the protective effect on liver injury against DOCA-salt administration
and the beneficial effect could be attributed to its antihyperlipidemic
activities.
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