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10.1038/ncomms6671 http://scihub22266oqcxt.onion/10.1038/ncomms6671 C4377070!4377070!25476932     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2014 ; 5 (ä): 5671 Nephropedia Template TP {{tp|p=25476932|t=2014. miR-205 acts as a tumor radiosensitizer by targeting ZEB1 and Ubc13 |pdf=|usr=}}{{25476932}} gab.com Text miR-205 acts as a tumor radiosensitizer by targeting ZEB1 and Ubc13 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25476932 #FOAvip Tumor cells associated with therapy resistance (radioresistance and drug resistance) are likely to give rise to local recurrence and distant metastatic relapse. Recent studies revealed microRNA (miRNA)-mediated regulation of metastasis and epithelial-mesenchymal transition; however, whether specific miRNAs regulate tumor radioresistance and can be exploited as radiosensitizing agents remains unclear. Here we find that miR-205 promotes radiosensitivity and is downregulated in radioresistant subpopulations of breast cancer cells, and that loss of miR-205 is highly associated with poor distant relapse-free survival in breast cancer patients. Notably, therapeutic delivery of miR-205 mimics via nanoliposomes can sensitize the tumor to radiation in a xenograft model. Mechanistically, radiation suppresses miR-205 expression through ataxia telangiectasia mutated (ATM) and zinc finger E-box binding homeobox 1 (ZEB1). Moreover, miR-205 inhibits DNA damage repair by targeting ZEB1 and the ubiquitin-conjugating enzyme Ubc13. These findings identify miR-205 as a radiosensitizing miRNA and reveal a new therapeutic strategy for radioresistant tumors. Twit Text FOAVip miR-205 acts as a tumor radiosensitizer by targeting ZEB1 and Ubc13 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25476932 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25476932 #FOAvip English Wikipedia <ref>{{Cite pmid|25476932}}</ref> miR-205 acts as a tumor radiosensitizer by targeting ZEB1 and Ubc13 #MMPMID25476932 Zhang P; Wang L; Rodriguez-Aguayo C; Yuan Y; Debeb BG; Chen D; Sun Y; You MJ; Liu Y; Dean DC; Woodward WA; Liang H; Yang X; Lopez-Berestein G; Sood AK; Hu Y; Ang KK; Chen J; Ma L Nat Commun 2014[]; 5 (ä): 5671 PMID25476932show ga Tumor cells associated with therapy resistance (radioresistance and drug resistance) are likely to give rise to local recurrence and distant metastatic relapse. Recent studies revealed microRNA (miRNA)-mediated regulation of metastasis and epithelial-mesenchymal transition; however, whether specific miRNAs regulate tumor radioresistance and can be exploited as radiosensitizing agents remains unclear. Here we find that miR-205 promotes radiosensitivity and is downregulated in radioresistant subpopulations of breast cancer cells, and that loss of miR-205 is highly associated with poor distant relapse-free survival in breast cancer patients. Notably, therapeutic delivery of miR-205 mimics via nanoliposomes can sensitize the tumor to radiation in a xenograft model. Mechanistically, radiation suppresses miR-205 expression through ataxia telangiectasia mutated (ATM) and zinc finger E-box binding homeobox 1 (ZEB1). Moreover, miR-205 inhibits DNA damage repair by targeting ZEB1 and the ubiquitin-conjugating enzyme Ubc13. These findings identify miR-205 as a radiosensitizing miRNA and reveal a new therapeutic strategy for radioresistant tumors. ämiR-205 acts as a tumor radiosensitizer by targeting ZEB1 and Ubc13 (epmc).pdf DeepDyve Pubget Overpricing