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10.1371/journal.pone.0119033 http://scihub22266oqcxt.onion/10.1371/journal.pone.0119033 C4376727!4376727!25816025     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (3): ä Nephropedia Template TP {{tp|p=25816025|t=2015. Urinary CXCL1: A Novel Predictor of IgA Nephropathy Progression |pdf=|usr=}}{{25816025}} gab.com Text Urinary CXCL1: A Novel Predictor of IgA Nephropathy Progression JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25816025 #FOAvip Background: IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. In recent years, consistent efforts have been made to develop new non-invasive biomarkers for IgAN progression. In our previous in vitro study we found mesangial derived CXCL1 as a contributor for kidney injury, and observed higher urinary CXCL1 levels in patients with IgAN. It implied that the urinary CXCL1 might be a potential biomarker. Methods: In the present study, we enrolled 425 IgAN patients with follow-up data and detected their urinary CXCL1 levels at the time of renal biopsy, to explore the predictive value of urinary CXCL1 in IgAN progression. Urinary CXCL1 levels were measured using enzyme-linked immunosorbent assay. Results: Urinary CXCL1 levels were associated with presently well established predictors of IgAN progression, including SBP (r = 0.138, p = 0.004), DBP (r = 0.114, p = 0.019), proteinuria (r = 0.155, p = 0.001), eGFR (r = -0.259, p<0.001) and tubular atrophy and interstitial fibrosis (r = 0.181, p<0.001). After adjusted for them, higher levels of urinary CXCL1 were independently associated with a greater risk of deterioration in renal function (HR, per s.d. increment of natural log?transformed CXCL1: 1.748; 95% CI: 1.222?2.499, P = 0.002). Furthermore, time-dependent receiver operating characteristic (ROC) curve showed that urinary CXCL1, when combined with proteinuria and eGFR, could enhance the prognostic value of these traditional predictors for IgAN progression. Conclusions: The results in our present study suggested urinary CXCL1 as a new non-invasive predictor of IgAN progression. Twit Text FOAVip Urinary CXCL1: A Novel Predictor of IgA Nephropathy Progression ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25816025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25816025 #FOAvip English Wikipedia <ref>{{Cite pmid|25816025}}</ref> Urinary CXCL1: A Novel Predictor of IgA Nephropathy Progression #MMPMID25816025 Zhao Y; Zhu L; Zhou T; Zhang Q; Shi S; Liu L; Lv J; Zhang H PLoS One 2015[]; 10 (3): ä PMID25816025show ga Background: IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. In recent years, consistent efforts have been made to develop new non-invasive biomarkers for IgAN progression. In our previous in vitro study we found mesangial derived CXCL1 as a contributor for kidney injury, and observed higher urinary CXCL1 levels in patients with IgAN. It implied that the urinary CXCL1 might be a potential biomarker. Methods: In the present study, we enrolled 425 IgAN patients with follow-up data and detected their urinary CXCL1 levels at the time of renal biopsy, to explore the predictive value of urinary CXCL1 in IgAN progression. Urinary CXCL1 levels were measured using enzyme-linked immunosorbent assay. Results: Urinary CXCL1 levels were associated with presently well established predictors of IgAN progression, including SBP (r = 0.138, p = 0.004), DBP (r = 0.114, p = 0.019), proteinuria (r = 0.155, p = 0.001), eGFR (r = -0.259, p<0.001) and tubular atrophy and interstitial fibrosis (r = 0.181, p<0.001). After adjusted for them, higher levels of urinary CXCL1 were independently associated with a greater risk of deterioration in renal function (HR, per s.d. increment of natural log?transformed CXCL1: 1.748; 95% CI: 1.222?2.499, P = 0.002). Furthermore, time-dependent receiver operating characteristic (ROC) curve showed that urinary CXCL1, when combined with proteinuria and eGFR, could enhance the prognostic value of these traditional predictors for IgAN progression. Conclusions: The results in our present study suggested urinary CXCL1 as a new non-invasive predictor of IgAN progression. äUrinary CXCL1: A Novel Predictor of IgA Nephropathy Progression (epmc).pdf DeepDyve Pubget Overpricing