Effect of N-acetylcysteine pretreatment of deceased organ donors on renal
allograft function: a randomized controlled trial
#MMPMID25250647
Orban JC
; Quintard H
; Cassuto E
; Jambou P
; Samat-Long C
; Ichai C
Transplantation
2015[Apr]; 99
(4
): 746-53
PMID25250647
show ga
BACKGROUND: Antioxidant donor pretreatment is one of the pharmacologic strategy
proposed to prevent renal ischemia-reperfusion injuries and delayed graft
function (DGF). The aim of the study was to investigate whether a donor
pretreatment with N-acetylcysteine (NAC) reduces the incidence of DGF in adult
human kidney transplant recipients. METHODS: In this randomized, open-label,
monocenter trial, 160 deceased heart-beating donors were allowed to perform 236
renal transplantations from September 2005 to December 2010. Donors were
randomized to receive, in a single-blind controlled fashion, 600 mg of
intravenous NAC 1 hr before and 2 hr after cerebral angiography performed to
confirm brain death. Primary endpoint was DGF defined by the need for at least
one dialysis session within the first week or a serum creatinine level greater
than 200 ?mol/L at day 7 after kidney transplantation. RESULTS: The incidence of
DGF was similar between donors pretreated with or without NAC (39/118; 33% vs.
30/118; 25.4%; P = 0.19). Requirement for at least one dialysis session was not
different between the NAC and No NAC groups (17/118; 14.4% vs. 14/118; 11.8%, P =
0.56). The two groups had comparable serum creatinine levels, estimated
glomerular filtration rates, and daily urine output at days 1, 7, 15, and 30
after kidney transplantation as well as at hospital discharge. No difference in
recipient mortality nor in 1-year kidney graft survival was observed. CONCLUSION:
Donor pretreatment with NAC does not improve delayed graft function after kidney
transplantation.
|*Tissue Donors
[MESH]
|Acetylcysteine/*administration & dosage
[MESH]
|Administration, Intravenous
[MESH]
|Adult
[MESH]
|Allografts
[MESH]
|Antioxidants/*administration & dosage
[MESH]
|Biomarkers/blood
[MESH]
|Brain Death/diagnosis
[MESH]
|Cerebral Angiography
[MESH]
|Creatinine/blood
[MESH]
|Delayed Graft Function/diagnosis/etiology/mortality/physiopathology/*prevention &
control
[MESH]
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