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10.4137/LPI.S24081

http://scihub22266oqcxt.onion/10.4137/LPI.S24081
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C4376205!4376205!25861222
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suck abstract from ncbi


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pmid25861222      Lipid+Insights 2015 ; 8 (ä): 1-9
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  • Free-radical Destruction of Sphingolipids Resulting in 2-hexadecenal Formation #MMPMID25861222
  • Shadyro O; Lisovskaya A; Semenkova G; Edimecheva I; Amaegberi N
  • Lipid Insights 2015[]; 8 (ä): 1-9 PMID25861222show ga
  • The action of hypochlorous acid (HOCl) and ?-radiation on aqueous lysosphingolipid dispersions was found to produce 2-hexadecenal (Hex). This process includes the stages of formation of nitrogen-centered radicals from the starting molecules and the subsequent fragmentation of these radicals via the rupture of C?C and O?H bonds. These findings prove the existence of a nonenzymatic pathway of sphingolipid destruction leading to the formation of Hex, which possesses a wide spectrum of biological activity. Analysis of the effect of HOCl on transplantable rat glioma C6 cells and human embryonic kidney 293 cells points to the formation of Hex. This suggests that the described mechanism of free-radical destruction of sphingolipids may be replicated on cell culture under the stress of active chlorine forms.
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