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10.1016/j.bpj.2014.12.045 http://scihub22266oqcxt.onion/10.1016/j.bpj.2014.12.045 C4375682!4375682!25762334     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biophys+J 2015 ; 108 (5): 1229-37 Nephropedia Template TP {{tp|p=25762334|t=2015. Intramembrane Proteolysis of ?-Amyloid Precursor Protein by ?-Secretase Is an Unusually Slow Process |pdf=|usr=}}{{25762334}} gab.com Text Intramembrane Proteolysis of -Amyloid Precursor Protein by -Secretase Is an Unusually Slow Process JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=25762334 #FOAvip Intramembrane proteolysis has emerged as a key mechanism required for membrane proteostasis and cellular signaling. One of the intramembrane-cleaving proteases (I-CLiPs), ?-secretase, is also intimately implicated in Alzheimer?s disease, a major neurodegenerative disease and leading cause of dementia. High-resolution crystal structural analyses have revealed that I-CLiPs harbor their active sites buried deeply in the membrane bilayer. Surprisingly, however, the key kinetic constants of these proteases, turnover number kcat and catalytic efficiency kcat/KM, are largely unknown. By investigating the kinetics of intramembrane cleavage of the Alzheimer?s disease-associated ?-amyloid precursor protein in vitro and in human embryonic kidney cells, we show that ?-secretase is a very slow protease with a kcat value similar to those determined recently for rhomboid-type I-CLiPs. Our results indicate that low turnover numbers may be a general feature of I-CLiPs. Twit Text FOAVip Intramembrane Proteolysis of -Amyloid Precursor Protein by -Secretase Is an Unusually Slow Process ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=25762334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25762334 #FOAvip English Wikipedia <ref>{{Cite pmid|25762334}}</ref> Intramembrane Proteolysis of ?-Amyloid Precursor Protein by ?-Secretase Is an Unusually Slow Process #MMPMID25762334 Kamp F; Winkler E; Trambauer J; Ebke A; Fluhrer R; Steiner H Biophys J 2015[Mar]; 108 (5): 1229-37 PMID25762334show ga Intramembrane proteolysis has emerged as a key mechanism required for membrane proteostasis and cellular signaling. One of the intramembrane-cleaving proteases (I-CLiPs), ?-secretase, is also intimately implicated in Alzheimer?s disease, a major neurodegenerative disease and leading cause of dementia. High-resolution crystal structural analyses have revealed that I-CLiPs harbor their active sites buried deeply in the membrane bilayer. Surprisingly, however, the key kinetic constants of these proteases, turnover number kcat and catalytic efficiency kcat/KM, are largely unknown. By investigating the kinetics of intramembrane cleavage of the Alzheimer?s disease-associated ?-amyloid precursor protein in vitro and in human embryonic kidney cells, we show that ?-secretase is a very slow protease with a kcat value similar to those determined recently for rhomboid-type I-CLiPs. Our results indicate that low turnover numbers may be a general feature of I-CLiPs. äIntramembrane Proteolysis of ?-Amyloid Precursor Protein by ?-Secretas(epmc).pdf DeepDyve Pubget Overpricing