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10.1074/jbc.M114.634915

http://scihub22266oqcxt.onion/10.1074/jbc.M114.634915
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suck abstract from ncbi


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pmid25645914      J+Biol+Chem 2015 ; 290 (13): 8613-22
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  • Post-translationally Abnormal Collagens of Prolyl 3-Hydroxylase-2 Null Mice Offer a Pathobiological Mechanism for the High Myopia Linked to Human LEPREL1 Mutations* #MMPMID25645914
  • Hudson DM; Joeng KS; Werther R; Rajagopal A; Weis M; Lee BH; Eyre DR
  • J Biol Chem 2015[Mar]; 290 (13): 8613-22 PMID25645914show ga
  • Background: Mutations in LEPREL1, the gene encoding prolyl 3-hydroxylase-2 (P3H2), cause severe nonsyndromic myopia.Results: Collagens I and IV from P3h2-null mouse eye tissues were significantly reduced in 3-hydroxylation compared with wild-type littermates.Conclusion: Loss of P3h2 causes altered collagen prolyl 3-hydroxylation from multiple tissues.Significance: Improved understanding of molecular mechanisms of myopia could aid in early diagnosis and treatment of irreversible vision loss.
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