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10.1074/jbc.M114.619270

http://scihub22266oqcxt.onion/10.1074/jbc.M114.619270
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C4375503!4375503!25670864
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suck abstract from ncbi


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pmid25670864      J+Biol+Chem 2015 ; 290 (13): 8539-49
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  • Structural Insights into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2* #MMPMID25670864
  • Newman JA; Cooper CDO; Aitkenhead H; Gileadi O
  • J Biol Chem 2015[Mar]; 290 (13): 8539-49 PMID25670864show ga
  • Background: ETS transcription factors regulate expression of genes involved in development and cancer.Results: Crystal structure of the Ets-2 DNA binding domain reveals how closely spaced binding sites are recognized.Conclusion: A significant difference in binding regulation is observed between the closely related Ets-1 and Ets-2 transcription factors.Significance: This may explain the different physiological roles of different Ets proteins.
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