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10.1074/jbc.M115.637496

http://scihub22266oqcxt.onion/10.1074/jbc.M115.637496
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C4375482!4375482!25670862
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suck abstract from ncbi


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pmid25670862      J+Biol+Chem 2015 ; 290 (13): 8271-82
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  • Tumor-secreted Hsp90 Subverts Polycomb Function to Drive Prostate Tumor Growth and Invasion* #MMPMID25670862
  • Nolan KD; Franco OE; Hance MW; Hayward SW; Isaacs JS
  • J Biol Chem 2015[Mar]; 290 (13): 8271-82 PMID25670862show ga
  • Background: Extracellular Hsp90 (eHsp90) is implicated in cancer cell motility and invasion.Results: Tumor eHsp90 regulates ERK signaling, EZH2 expression, and histone methylation to facilitate prostate tumor growth and invasion.Conclusion: Newly characterized epigenetic functions of eHsp90 contribute to prostate tumorigenesis.Significance: Epigenetic modulation by eHsp90 may be a key facilitator in the transition of indolent to aggressive disease, highlighting a novel molecular effector of disease progression.
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