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10.1074/jbc.M114.623074

http://scihub22266oqcxt.onion/10.1074/jbc.M114.623074
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suck abstract from ncbi


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pmid25623072      J+Biol+Chem 2015 ; 290 (13): 8232-42
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  • The Matricellular Protein Cyr61 Is a Key Mediator of Platelet-derived Growth Factor-induced Cell Migration* #MMPMID25623072
  • Zhang F; Hao F; An D; Zeng L; Wang Y; Xu X; Cui MZ
  • J Biol Chem 2015[Mar]; 290 (13): 8232-42 PMID25623072show ga
  • Background: PDGF is a potent chemoattractant for cells.Results: The PDGF-induced extracellular matrix component Cyr61 bridges the intracellular PDGF-ERK and JNK signaling pathways with integrin/FAK signaling, leading to cell migration.Conclusion: Cyr61 is a key mediator of PDGF-induced cell migration via the Cyr61-integrin-FAK pathway.Significance: Extracellular Cyr61 convergence with growth factor and integrin/FAK signaling is a new cell migration concept.
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