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10.1074/jbc.M114.623074 http://scihub22266oqcxt.onion/10.1074/jbc.M114.623074 C4375479!4375479 !25623072     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25623072 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2015 ; 290 (13 ): 8232-42 Nephropedia Template TP {{tp|p=25623072 |t=2015. The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration |pdf=|usr=}}{{25623072 }} gab.com Text The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25623072 #FOAvip Platelet-derived growth factor (PDGF), a potent chemoattractant, induces cell migration via the MAPK and PI3K/Akt pathways. However, the downstream mediators are still elusive. In particular, the role of extracellular mediators is largely unknown. In this study, we identified the matricellular protein Cyr61, which is de novo synthesized in response to PDGF stimulation, as the key downstream mediator of the ERK and JNK pathways, independent of the p38 MAPK and AKT pathways, and, thereby, it mediates PDGF-induced smooth muscle cell migration but not proliferation. Our results revealed that, when Cyr61 was newly synthesized by PDGF, it was promptly translocated to the extracellular matrix and physically interacted with the plasma membrane integrins ?6?1 and ?v?3. We further demonstrate that Cyr61 and integrins are integral components of the PDGF signaling pathway via an "outside-in" signaling route to activate intracellular focal adhesion kinase (FAK), leading to cell migration. Therefore, this study provides the first evidence that the PDGF-induced endogenous extracellular matrix component Cyr61 is a key mediator in modulating cell migration by connecting intracellular PDGF-ERK and JNK signals with integrin/FAK signaling. Therefore, extracellular Cyr61 convergence with growth factor signaling and integrin/FAK signaling is a new concept of growth factor-induced cell migration. The discovered signaling pathway may represent an important therapeutic target in growth factor-mediated cell migration/invasion-related vascular diseases and tumorigenesis. Twit Text FOAVip The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25623072 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25623072 #FOAvip English Wikipedia <ref>{{Cite pmid|25623072 }}</ref> The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration #MMPMID25623072 Zhang F ; Hao F ; An D ; Zeng L ; Wang Y ; Xu X ; Cui MZ J Biol Chem 2015[Mar]; 290 (13 ): 8232-42 PMID25623072 show ga Platelet-derived growth factor (PDGF), a potent chemoattractant, induces cell migration via the MAPK and PI3K/Akt pathways. However, the downstream mediators are still elusive. In particular, the role of extracellular mediators is largely unknown. In this study, we identified the matricellular protein Cyr61, which is de novo synthesized in response to PDGF stimulation, as the key downstream mediator of the ERK and JNK pathways, independent of the p38 MAPK and AKT pathways, and, thereby, it mediates PDGF-induced smooth muscle cell migration but not proliferation. Our results revealed that, when Cyr61 was newly synthesized by PDGF, it was promptly translocated to the extracellular matrix and physically interacted with the plasma membrane integrins ?6?1 and ?v?3. We further demonstrate that Cyr61 and integrins are integral components of the PDGF signaling pathway via an "outside-in" signaling route to activate intracellular focal adhesion kinase (FAK), leading to cell migration. Therefore, this study provides the first evidence that the PDGF-induced endogenous extracellular matrix component Cyr61 is a key mediator in modulating cell migration by connecting intracellular PDGF-ERK and JNK signals with integrin/FAK signaling. Therefore, extracellular Cyr61 convergence with growth factor signaling and integrin/FAK signaling is a new concept of growth factor-induced cell migration. The discovered signaling pathway may represent an important therapeutic target in growth factor-mediated cell migration/invasion-related vascular diseases and tumorigenesis. |*Cell Movement [MESH] |Animals [MESH] |Becaplermin [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Cysteine-Rich Protein 61/*physiology [MESH] |Enzyme Activation [MESH] |Extracellular Matrix/metabolism [MESH] |Focal Adhesion Protein-Tyrosine Kinases/metabolism [MESH] |Integrins/metabolism [MESH] |MAP Kinase Signaling System [MESH] |Mice [MESH] |Myocytes, Smooth Muscle/physiology [MESH] |Proto-Oncogene Proteins c-sis/*physiology [MESH]The matricellular protein Cyr61 is a key mediator of platelet-derived (epmc).pdf DeepDyve Pubget Overpricing