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10.1074/jbc.M114.618736

http://scihub22266oqcxt.onion/10.1074/jbc.M114.618736
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suck abstract from ncbi


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pmid25673690      J+Biol+Chem 2015 ; 290 (13): 8049-64
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  • Characterization and Mechanism of Stress-induced Translocation of 78-Kilodalton Glucose-regulated Protein (GRP78) to the Cell Surface* #MMPMID25673690
  • Tsai YL; Zhang Y; Tseng CC; Stanciauskas R; Pinaud F; Lee AS
  • J Biol Chem 2015[Mar]; 290 (13): 8049-64 PMID25673690show ga
  • Background: ER stress induces cell surface translocation of GRP78/BiP.Results: GRP78 translocation to the cell surface requires its substrate binding domain and exists majorly as a peripheral protein.Conclusion: GRP78 anchors on the cell surface via interaction with other proteins, and the translocation mechanism is cell context-dependent.Significance: Learning how GRP78 exists on the cell surface is crucial for understanding its signaling regulatory functions.
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