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10.1097/ACI.0000000000000108

http://scihub22266oqcxt.onion/10.1097/ACI.0000000000000108
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C4374802!4374802!25159182
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suck abstract from ncbi


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pmid25159182      Curr+Opin+Allergy+Clin+Immunol 2014 ; 14 (6): 570-5
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  • Anti-Interleukin 4 and 13 for Asthma Treatment in the Era of Endotypes #MMPMID25159182
  • Kau AL; Korenblat PE
  • Curr Opin Allergy Clin Immunol 2014[Dec]; 14 (6): 570-5 PMID25159182show ga
  • Purpose of review: To summarize recent advances in interleukin (IL)-4 and IL-13 blockade in the treatment of asthma. Recent findings: Historically, anti-cytokine therapies have historically been unsuccessful in the treatment of asthma because of the heterogeneity of asthma. Recent advances in our understanding of asthma pathophysiology and our increased ability to phenotype patients has led to the identification of asthmatic subsets (endotypes) that are most likely to respond to anti-cytokine therapy. Several new biologic therapies targeting IL-13 or both IL-4 and IL-13 signaling are currently in clinical trials both types of therapies have demonstrated therapeutic benefit. Summary: Anti-IL-4/13 therapies, guided by knowledge of an individuals? underlying pathophysiology, are a promising class of therapies for treatment of asthma.
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