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10.1016/j.devcel.2015.01.031 http://scihub22266oqcxt.onion/10.1016/j.devcel.2015.01.031 C4374128!4374128!25805136     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Cell 2015 ; 32 (6): 707-18 Nephropedia Template TP {{tp|p=25805136|t=2015. FOXKs promote Wnt/?-catenin signaling by translocating DVL into the nucleus |pdf=|usr=}}{{25805136}} gab.com Text FOXKs promote Wnt/ -catenin signaling by translocating DVL into the nucleus JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25805136 #FOAvip Dishevelled (DVL) proteins serve as crucial regulators that transduce canonical Wnt signals to the GSK3?-destruction complex, resulting in the stabilization of ?-catenin. Emerging evidences underscore the nuclear functions of DVLs, which are critical for the Wnt/?-catenin signaling. However, the mechanism underlying DVL nuclear localization remains poorly understood. Here, we discovered two Forkhead box (FOX) transcription factors, FOXK1 and FOXK2, as bona-fide DVL-interacting proteins. FOXK1 and FOXK2 positively regulate Wnt/?-catenin signaling by translocating DVL into the nucleus. Moreover, FOXK1 and FOXK2 protein levels are elevated in human colorectal cancers and correlate with DVL nuclear localization. The conditional expression of Foxk2 in mice induced intestinal hyper-proliferation that featured with enhanced DVL-nuclear localization and up-regulated Wnt/?-catenin signaling. Together, our results not only reveal a mechanism by which DVL is translocated into nucleus, but also suggest unexpected roles of FOXK1 and FOXK2 in regulating Wnt/?-catenin signaling. Twit Text FOAVip FOXKs promote Wnt/ -catenin signaling by translocating DVL into the nucleus ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25805136 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25805136 #FOAvip English Wikipedia <ref>{{Cite pmid|25805136}}</ref> FOXKs promote Wnt/?-catenin signaling by translocating DVL into the nucleus #MMPMID25805136 Wang W; Li X; Lee M; Jun S; Aziz KE; Feng L; Tran MK; Li N; McCrea PD; Park JI; Chen J Dev Cell 2015[Mar]; 32 (6): 707-18 PMID25805136show ga Dishevelled (DVL) proteins serve as crucial regulators that transduce canonical Wnt signals to the GSK3?-destruction complex, resulting in the stabilization of ?-catenin. Emerging evidences underscore the nuclear functions of DVLs, which are critical for the Wnt/?-catenin signaling. However, the mechanism underlying DVL nuclear localization remains poorly understood. Here, we discovered two Forkhead box (FOX) transcription factors, FOXK1 and FOXK2, as bona-fide DVL-interacting proteins. FOXK1 and FOXK2 positively regulate Wnt/?-catenin signaling by translocating DVL into the nucleus. Moreover, FOXK1 and FOXK2 protein levels are elevated in human colorectal cancers and correlate with DVL nuclear localization. The conditional expression of Foxk2 in mice induced intestinal hyper-proliferation that featured with enhanced DVL-nuclear localization and up-regulated Wnt/?-catenin signaling. Together, our results not only reveal a mechanism by which DVL is translocated into nucleus, but also suggest unexpected roles of FOXK1 and FOXK2 in regulating Wnt/?-catenin signaling. äFOXKs promote Wnt/?-catenin signaling by translocating DVL into the nu(epmc).pdf DeepDyve Pubget Overpricing