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The Chronic Bronchitis Phenotype in COPD: Features and Implications #MMPMID25575367
Kim V; Criner GJ
Curr Opin Pulm Med 2015[Mar]; 21 (2): 133-41 PMID25575367show ga
Purpose of Review: Chronic Obstructive Pulmonary Disease (COPD) is a major public health problem that is projected to rank fifth worldwide in terms of disease burden and third in terms of mortality. Chronic bronchitis (CB) is associated with multiple clinical consequences, including hastening lung function decline, increasing risk of exacerbations, reducing health related quality of life, and possibly raising all-cause mortality. Recent data suggests greater elucidation on the risk factors, radiologic characteristics, and treatment regimens. Our goal was to review the literature on chronic bronchitis that has been published in the last few years. Recent Findings: A growing body of literature that more carefully describes environmental risk factors, epidemiology, and genetics associated with CB. In addition, as computed tomography technology continues to improve, the radiologic phenotype associated with CB is better understood. Summary: With these new data, the clinician can recognize the newly described risk factors and the associated phenotype for chronic bronchitis and entertain new treatment options for this high risk population.