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10.3389/fmicb.2015.00222

http://scihub22266oqcxt.onion/10.3389/fmicb.2015.00222
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C4373389!4373389!25859243
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suck abstract from ncbi


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pmid25859243      Front+Microbiol 2015 ; 6 (ä): ä
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  • Hantavirus-induced disruption of the endothelial barrier: neutrophils are on the payroll #MMPMID25859243
  • Schönrich G; Krüger DH; Raftery MJ
  • Front Microbiol 2015[]; 6 (ä): ä PMID25859243show ga
  • Viral hemorrhagic fever caused by hantaviruses is an emerging infectious disease for which suitable treatments are not available. In order to improve this situation a better understanding of hantaviral pathogenesis is urgently required. Hantaviruses infect endothelial cell layers in vitro without causing any cytopathogenic effect and without increasing permeability. This implies that the mechanisms underlying vascular hyperpermeability in hantavirus-associated disease are more complex and that immune mechanisms play an important role. In this review we highlight the latest developments in hantavirus-induced immunopathogenesis. A possible contribution of neutrophils has been neglected so far. For this reason, we place special emphasis on the pathogenic role of neutrophils in disrupting the endothelial barrier.
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