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10.1016/j.semnephrol.2014.06.005

http://scihub22266oqcxt.onion/10.1016/j.semnephrol.2014.06.005
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C4373354!4373354!25217267
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suck abstract from ncbi

pmid25217267      Semin+Nephrol 2014 ; 34 (4): 384-93
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  • Bioengineering Kidneys for Transplantation #MMPMID25217267
  • Madariaga MLL; Ott HC
  • Semin Nephrol 2014[Jul]; 34 (4): 384-93 PMID25217267show ga
  • One in ten Americans suffer from chronic kidney disease, and close to 90,000 people die each year from causes related to kidney failure. Patients with end-stage renal disease are faced with two options: hemodialysis or transplantation. Unfortunately, the reach of transplantation is limited because of the shortage of donor organs and the need for immunosuppression. Bioengineered kidney grafts theoretically present a novel solution to both problems. Herein we discuss the history of bioengineering organs, the current status of bioengineered kidneys, considerations for the future of the field, and challenges to clinical translation. We hope that by integrating principles of tissue engineering, and stem cell and developmental biology, bioengineered kidney grafts will advance the field of regenerative medicine while meeting a critical clinical need.
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