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10.1128/MCB.00765-14 http://scihub22266oqcxt.onion/10.1128/MCB.00765-14 C4372702!4372702 !25691658     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25691658 &cmd=llinks): Failed to open stream: HTTP request failed! 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YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues |pdf=|usr=}}{{25691658 }} gab.com Text YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues JO: Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25691658 #FOAvip Yes-associated protein (YAP) is a Hippo signaling transcriptional coactivator that plays pivotal roles in stem cell proliferation, organ size control, and tumor development. The downstream targets of YAP have been shown to be highly context dependent. In this study, we used the embryonic mouse tooth germ as a tool to search for the downstream targets of YAP in ectoderm-derived tissues. Yap deficiency in the dental epithelium resulted in a small tooth germ with reduced epithelial cell proliferation. We compared the gene expression profiles of embryonic day 14.5 (E14.5) Yap conditional knockout and YAP transgenic mouse tooth germs using transcriptome sequencing (RNA-Seq) and further confirmed the differentially expressed genes using real-time PCR and in situ hybridization. We found that YAP regulates the expression of Hoxa1 and Hoxc13 in oral and dental epithelial tissues as well as in the epidermis of skin during embryonic and adult stages. Sphere formation assay suggested that Hoxa1 and Hoxc13 are functionally involved in YAP-regulated epithelial progenitor cell proliferation, and chromatin immunoprecipitation (ChIP) assay implies that YAP may regulate Hoxa1 and Hoxc13 expression through TEAD transcription factors. These results provide mechanistic insights into abnormal YAP activities in mice and humans. Twit Text FOAVip YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues ????Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25691658 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25691658 #FOAvip English Wikipedia <ref>{{Cite pmid|25691658 }}</ref> YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues #MMPMID25691658 Liu M ; Zhao S ; Lin Q ; Wang XP Mol Cell Biol 2015[Apr]; 35 (8 ): 1449-61 PMID25691658 show ga Yes-associated protein (YAP) is a Hippo signaling transcriptional coactivator that plays pivotal roles in stem cell proliferation, organ size control, and tumor development. The downstream targets of YAP have been shown to be highly context dependent. In this study, we used the embryonic mouse tooth germ as a tool to search for the downstream targets of YAP in ectoderm-derived tissues. Yap deficiency in the dental epithelium resulted in a small tooth germ with reduced epithelial cell proliferation. We compared the gene expression profiles of embryonic day 14.5 (E14.5) Yap conditional knockout and YAP transgenic mouse tooth germs using transcriptome sequencing (RNA-Seq) and further confirmed the differentially expressed genes using real-time PCR and in situ hybridization. We found that YAP regulates the expression of Hoxa1 and Hoxc13 in oral and dental epithelial tissues as well as in the epidermis of skin during embryonic and adult stages. Sphere formation assay suggested that Hoxa1 and Hoxc13 are functionally involved in YAP-regulated epithelial progenitor cell proliferation, and chromatin immunoprecipitation (ChIP) assay implies that YAP may regulate Hoxa1 and Hoxc13 expression through TEAD transcription factors. These results provide mechanistic insights into abnormal YAP activities in mice and humans. |*Gene Expression Regulation, Developmental [MESH] |Adaptor Proteins, Signal Transducing/genetics/*metabolism [MESH] |Animals [MESH] |Cell Cycle Proteins [MESH] |Cell Line [MESH] |Cell Proliferation [MESH] |Epithelial Cells/cytology/*metabolism [MESH] |Homeodomain Proteins/*genetics [MESH] |Humans [MESH] |Keratinocytes/cytology/metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Mouth Mucosa/cytology/growth & development/metabolism [MESH] |Phosphoproteins/genetics/*metabolism [MESH] |Skin/cytology/growth & development/metabolism [MESH] |Tooth/cytology/growth & development/metabolism [MESH] |Transcription Factors/*genetics [MESH]YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human or(epmc).pdf DeepDyve Pubget Overpricing