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10.1097/COC.0000000000000128 http://scihub22266oqcxt.onion/10.1097/COC.0000000000000128 C4372498!4372498!25222071     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25222071&cmd=llinks): Failed to open stream: HTTP request failed! 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Outcomes of Adults with Ewing?s Sarcoma Family of Tumors (ESFT) of the Kidney: A Single Institution Experience |pdf=|usr=}}{{25222071}} gab.com Text Outcomes of Adults with Ewing s Sarcoma Family of Tumors (ESFT) of the Kidney: A Single Institution Experience JO: Am J Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25222071 #FOAvip Background: Ewing?s sarcoma family of tumors (ESFT) of the kidney are exceedingly rare. Given the rarity of this neoplasm and the complexity associated with its management, information regarding treatment and outcome is warranted. Methods: We conducted a retrospective study of patients with ESFT of the kidney who were treated at MDACC between 1/1/2001 and 1/1/2011. Descriptive statistics were used. Results: Thirteen patients were identified. (Median age 33 years; male:female 11:2). Common presenting symptoms were back pain, flank pain and hematuria. Six patients had metastatic disease at presentation. Initial diagnostic biopsy was performed in six patients. Immunohistochemistry showed strong positivity for CD99 (mic2) and cytogenetic analysis demonstrated evidence of EWSR1 fusion gene in eight cases. Nine patients underwent nephrectomy. Frequently used chemotherapy regimens consisted of vincristine, doxorubicin, and ifosfamide. Median overall survival (OS) was 17.2 months. Three patients were alive at the time of analysis, at 2 years, 7 years and 11 years from diagnosis (the latter without evidence of disease). Conclusion: Renal ESFT carry a guarded prognosis with limited response to therapy and short median OS. For patients with metastatic disease, diagnostic biopsy and sarcoma-based chemotherapy regimens are recommended as upfront therapeutic strategy. The role of nephrectomy in the metastatic setting is unclear. Future studies with novel therapies are needed. Twit Text FOAVip Outcomes of Adults with Ewing s Sarcoma Family of Tumors (ESFT) of the Kidney: A Single Institution Experience ????Am J Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25222071 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25222071 #FOAvip English Wikipedia <ref>{{Cite pmid|25222071}}</ref> Outcomes of Adults with Ewing?s Sarcoma Family of Tumors (ESFT) of the Kidney: A Single Institution Experience #MMPMID25222071 Teegavarapu PS; Rao P; Matrana MR; Cauley DH; Wood C; Patel S; Tannir NM Am J Clin Oncol 2017[Apr]; 40 (2): 189-93 PMID25222071show ga Background: Ewing?s sarcoma family of tumors (ESFT) of the kidney are exceedingly rare. Given the rarity of this neoplasm and the complexity associated with its management, information regarding treatment and outcome is warranted. Methods: We conducted a retrospective study of patients with ESFT of the kidney who were treated at MDACC between 1/1/2001 and 1/1/2011. Descriptive statistics were used. Results: Thirteen patients were identified. (Median age 33 years; male:female 11:2). Common presenting symptoms were back pain, flank pain and hematuria. Six patients had metastatic disease at presentation. Initial diagnostic biopsy was performed in six patients. Immunohistochemistry showed strong positivity for CD99 (mic2) and cytogenetic analysis demonstrated evidence of EWSR1 fusion gene in eight cases. Nine patients underwent nephrectomy. Frequently used chemotherapy regimens consisted of vincristine, doxorubicin, and ifosfamide. Median overall survival (OS) was 17.2 months. Three patients were alive at the time of analysis, at 2 years, 7 years and 11 years from diagnosis (the latter without evidence of disease). Conclusion: Renal ESFT carry a guarded prognosis with limited response to therapy and short median OS. For patients with metastatic disease, diagnostic biopsy and sarcoma-based chemotherapy regimens are recommended as upfront therapeutic strategy. The role of nephrectomy in the metastatic setting is unclear. Future studies with novel therapies are needed. äOutcomes of Adults with Ewing?s Sarcoma Family of Tumors (ESFT) of the(epmc).pdf DeepDyve Pubget Overpricing