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10.1016/j.neuron.2014.09.022 http://scihub22266oqcxt.onion/10.1016/j.neuron.2014.09.022 C4372249!4372249!25308330     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuron 2014 ; 84 (2): 432-41 Nephropedia Template TP {{tp|p=25308330|t=2014. Direct reactivation of a coherent neocortical memory of context |pdf=|usr=}}{{25308330}} gab.com Text Direct reactivation of a coherent neocortical memory of context JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=25308330 #FOAvip Declarative memories are thought to be stored within anatomically distributed neuronal networks requiring the hippocampus; however, it is unclear how neocortical areas participate in memory at the time of encoding. Here, we use a c-fos-based genetic tagging system to selectively express the channelrhodopsin variant, ChEF, and optogenetically reactivate a specific neural ensemble in retrosplenial cortex (RSC) engaged by context fear conditioning. Artificial stimulation of RSC was sufficient to produce both context-specific behavior and downstream cellular activity commensurate with natural experience. Moreover, optogenetically, but not contextually-elicited responses were insensitive to hippocampal inactivation, suggesting that although the hippocampus is needed to coordinate activation by sensory cues, a higher-order cortical framework can independently subserve learned behavior, even shortly after learning. Twit Text FOAVip Direct reactivation of a coherent neocortical memory of context ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=25308330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25308330 #FOAvip English Wikipedia <ref>{{Cite pmid|25308330}}</ref> Direct reactivation of a coherent neocortical memory of context #MMPMID25308330 Cowansage KK; Shuman T; Dillingham BC; Chang A; Golshani P; Mayford M Neuron 2014[Oct]; 84 (2): 432-41 PMID25308330show ga Declarative memories are thought to be stored within anatomically distributed neuronal networks requiring the hippocampus; however, it is unclear how neocortical areas participate in memory at the time of encoding. Here, we use a c-fos-based genetic tagging system to selectively express the channelrhodopsin variant, ChEF, and optogenetically reactivate a specific neural ensemble in retrosplenial cortex (RSC) engaged by context fear conditioning. Artificial stimulation of RSC was sufficient to produce both context-specific behavior and downstream cellular activity commensurate with natural experience. Moreover, optogenetically, but not contextually-elicited responses were insensitive to hippocampal inactivation, suggesting that although the hippocampus is needed to coordinate activation by sensory cues, a higher-order cortical framework can independently subserve learned behavior, even shortly after learning. äDirect reactivation of a coherent neocortical memory of context (epmc).pdf DeepDyve Pubget Overpricing