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10.1073/pnas.1414558112 http://scihub22266oqcxt.onion/10.1073/pnas.1414558112 C4371937!4371937!25737556     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (11): 3457-62 Nephropedia Template TP {{tp|p=25737556|t=2015. Quorum-sensing Salmonella selectively trigger protein expression within tumors |pdf=|usr=}}{{25737556}} gab.com Text Quorum-sensing Salmonella selectively trigger protein expression within tumors JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25737556 #FOAvip Nonpathogenic Salmonella localize to tumors and can be engineered to secrete anticancer proteins, but tumor-specific expression is essential to prevent systemic toxicity. To reduce unwanted side effects in healthy tissue, we integrated Salmonella with a quorum-sensing (QS) switch that only initiates drug expression in the tightly packed colonies present within tumors. Using an in vitro 3D-tumor-on-a-chip device and in vivo mouse models, we show that QS Salmonella specifically initiates protein expression within cancerous tissue while remaining uninduced in livers. Protein expression was triggered when inducer molecules from enough close neighbors reached a critical concentration. Because of these selective qualities, QS Salmonella are a promising tool for tumor-specific delivery of therapeutic proteins. Twit Text FOAVip Quorum-sensing Salmonella selectively trigger protein expression within tumors ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25737556 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25737556 #FOAvip English Wikipedia <ref>{{Cite pmid|25737556}}</ref> Quorum-sensing Salmonella selectively trigger protein expression within tumors #MMPMID25737556 Swofford CA; Van Dessel N; Forbes NS Proc Natl Acad Sci U S A 2015[Mar]; 112 (11): 3457-62 PMID25737556show ga Nonpathogenic Salmonella localize to tumors and can be engineered to secrete anticancer proteins, but tumor-specific expression is essential to prevent systemic toxicity. To reduce unwanted side effects in healthy tissue, we integrated Salmonella with a quorum-sensing (QS) switch that only initiates drug expression in the tightly packed colonies present within tumors. Using an in vitro 3D-tumor-on-a-chip device and in vivo mouse models, we show that QS Salmonella specifically initiates protein expression within cancerous tissue while remaining uninduced in livers. Protein expression was triggered when inducer molecules from enough close neighbors reached a critical concentration. Because of these selective qualities, QS Salmonella are a promising tool for tumor-specific delivery of therapeutic proteins. äQuorum-sensing Salmonella selectively trigger protein expression withi(epmc).pdf DeepDyve Pubget Overpricing