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10.3389/fgene.2015.00091 http://scihub22266oqcxt.onion/10.3389/fgene.2015.00091 C4371746!4371746!25852739     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Genet 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=25852739|t=2015. On the road with WRAP53?: guardian of Cajal bodies and genome integrity |pdf=|usr=}}{{25852739}} gab.com Text On the road with WRAP53 : guardian of Cajal bodies and genome integrity JO: Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=25852739 #FOAvip The WRAP53 gene encodes both an antisense transcript (WRAP53?) that stabilizes the tumor suppressor p53 and a protein (WRAP53?) involved in maintenance of Cajal bodies, telomere elongation and DNA repair. WRAP53? is one of many proteins containing WD40 domains, known to mediate a variety of cellular processes. These proteins lack enzymatic activity, acting instead as platforms for the assembly of large complexes of proteins and RNAs thus facilitating their interactions. WRAP53? mediates site-specific interactions between Cajal body factors and DNA repair proteins. Moreover, dysfunction of this protein has been linked to premature aging, cancer and neurodegeneration. Here we summarize the current state of knowledge concerning the multifaceted roles of WRAP53? in intracellular trafficking, formation of the Cajal body, DNA repair and maintenance of genomic integrity and discuss potential crosstalk between these processes. Twit Text FOAVip On the road with WRAP53 : guardian of Cajal bodies and genome integrity ????Front Genet http://www.kidney.de/pget.php?&tw=1&pmid=25852739 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25852739 #FOAvip English Wikipedia <ref>{{Cite pmid|25852739}}</ref> On the road with WRAP53?: guardian of Cajal bodies and genome integrity #MMPMID25852739 Henriksson S; Farnebo M Front Genet 2015[]; 6 (ä): ä PMID25852739show ga The WRAP53 gene encodes both an antisense transcript (WRAP53?) that stabilizes the tumor suppressor p53 and a protein (WRAP53?) involved in maintenance of Cajal bodies, telomere elongation and DNA repair. WRAP53? is one of many proteins containing WD40 domains, known to mediate a variety of cellular processes. These proteins lack enzymatic activity, acting instead as platforms for the assembly of large complexes of proteins and RNAs thus facilitating their interactions. WRAP53? mediates site-specific interactions between Cajal body factors and DNA repair proteins. Moreover, dysfunction of this protein has been linked to premature aging, cancer and neurodegeneration. Here we summarize the current state of knowledge concerning the multifaceted roles of WRAP53? in intracellular trafficking, formation of the Cajal body, DNA repair and maintenance of genomic integrity and discuss potential crosstalk between these processes. äOn the road with WRAP53?: guardian of Cajal bodies and genome integrit(epmc).pdf DeepDyve Pubget Overpricing