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2015 ; 10
(ä): 613-23
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Early impact of treatment with tiotropium, long-acting anticholinergic
preparation, in patients with COPD - real-life experience from an observational
study
#MMPMID25834420
Jahnz-Ró?yk K
; Szepiel P
Int J Chron Obstruct Pulmon Dis
2015[]; 10
(ä): 613-23
PMID25834420
show ga
BACKGROUND: Long-acting inhaled bronchodilators, including anticholinergic
tiotropium, are recommended for the maintenance therapy of chronic obstructive
pulmonary disease (COPD). It has been shown in a number of studies that treatment
with tiotropium alleviates symptoms, improves exercise tolerance, health status,
and reduces exacerbations in patients with moderate to very severe stage COPD.
AIM: The aim of this noninterventional study was to observe the early effects of
the maintenance treatment with tiotropium in patients with COPD of different
severities, who had been previously treated on a regular basis, or as required,
with at least one short-acting bronchodilator, in a real-life setting in Poland.
The effect of the treatment was assessed through the collection of COPD
Assessment Test (CAT) data. PATIENTS AND METHODS: The MATHS clinical study was an
observational, noninterventional, open-label, prospective, uncontrolled,
single-arm, postmarketing, surveillance, real-life study conducted with the
involvement of 236 pulmonology clinics based in Poland. The tiotropium
observational period was 3 months. The health and COPD status was measured with
the CAT questionnaire. The primary efficacy endpoint was the mean change from the
baseline in the total CAT score at the end of the 3-month observational period.
RESULTS: Patients treated with 18 ?g of tiotropium once daily for 3 months showed
a statistically significant result, with a clinically meaningful mean reduction
(improvement) of 7.0 points in the total CAT score. The improvement was slightly
greater in patients with more severe COPD; the mean change in the total CAT score
was 7.6 in the subgroup of patients with more severe COPD and 6.7 points in the
subgroup of patients with moderate COPD. CONCLUSION: Results of this real-life
study provide further support for the use of tiotropium as a first-line
maintenance treatment for patients with COPD of different severities in Poland.
|Aged
[MESH]
|Bronchodilator Agents/adverse effects/*therapeutic use
[MESH]
|Cholinergic Antagonists/adverse effects/*therapeutic use
[MESH]