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10.1371/journal.pone.0120162 http://scihub22266oqcxt.onion/10.1371/journal.pone.0120162 C4370659!4370659 !25799278     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25799278 &cmd=llinks): Failed to open stream: HTTP request failed! 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Lewisy promotes migration of oral cancer cells by glycosylation of epidermal growth factor receptor |pdf=|usr=}}{{25799278 }} gab.com Text Lewisy promotes migration of oral cancer cells by glycosylation of epidermal growth factor receptor JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25799278 #FOAvip Aberrant glycosylation changes normal cellular functions and represents a specific hallmark of cancer. Lewisy (Ley) carbohydrate upregulation has been reported in a variety of cancers, including oral squamous cell carcinoma (OSCC). A high level of Ley expression is related to poor prognosis of patients with oral cancer. However, it is unclear how Ley mediates oral cancer progression. In this study, the role of Ley in OSCC was explored. Our data showed that Ley was upregulated in HSC-3 and OC-2 OSCC cell lines. Particularly, glycosylation of epidermal growth factor receptor (EGFR) with Ley was found in OC-2 cells, and this modification was absent upon inhibition of Ley synthesis. The absence of Ley glycosylation of EGFR weakened phosphorylation of AKT and ERK in response to epidermal growth factor (EGF). Additionally, EGF-triggered cell migration was reduced, but cell proliferation was not affected. Ley modification stabilized EGFR upon ligand activation. Conversely, absence of Ley glycosylation accelerated EGFR degradation. In summary, these results indicate that increased expression of Ley in OSCC cells is able to promote cell migration by modifying EGFR which in turn stabilizes EGFR expression and downstream signaling. Targeting Ley on EGFR could have a potential therapeutic effect on oral cancer. Twit Text FOAVip Lewisy promotes migration of oral cancer cells by glycosylation of epidermal growth factor receptor ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25799278 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25799278 #FOAvip English Wikipedia <ref>{{Cite pmid|25799278 }}</ref> Lewisy promotes migration of oral cancer cells by glycosylation of epidermal growth factor receptor #MMPMID25799278 Lin WL ; Lin YS ; Shi GY ; Chang CF ; Wu HL PLoS One 2015[]; 10 (3 ): e0120162 PMID25799278 show ga Aberrant glycosylation changes normal cellular functions and represents a specific hallmark of cancer. Lewisy (Ley) carbohydrate upregulation has been reported in a variety of cancers, including oral squamous cell carcinoma (OSCC). A high level of Ley expression is related to poor prognosis of patients with oral cancer. However, it is unclear how Ley mediates oral cancer progression. In this study, the role of Ley in OSCC was explored. Our data showed that Ley was upregulated in HSC-3 and OC-2 OSCC cell lines. Particularly, glycosylation of epidermal growth factor receptor (EGFR) with Ley was found in OC-2 cells, and this modification was absent upon inhibition of Ley synthesis. The absence of Ley glycosylation of EGFR weakened phosphorylation of AKT and ERK in response to epidermal growth factor (EGF). Additionally, EGF-triggered cell migration was reduced, but cell proliferation was not affected. Ley modification stabilized EGFR upon ligand activation. Conversely, absence of Ley glycosylation accelerated EGFR degradation. In summary, these results indicate that increased expression of Ley in OSCC cells is able to promote cell migration by modifying EGFR which in turn stabilizes EGFR expression and downstream signaling. Targeting Ley on EGFR could have a potential therapeutic effect on oral cancer. |*Cell Movement [MESH] |*Protein Processing, Post-Translational [MESH] |Carcinoma, Squamous Cell/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cells, Cultured [MESH] |ErbB Receptors/*metabolism [MESH] |Extracellular Signal-Regulated MAP Kinases/metabolism [MESH] |Glycosylation [MESH] |Humans [MESH] |Keratinocytes/metabolism/physiology [MESH] |Lewis Blood Group Antigens/genetics/*metabolism [MESH] |Male [MESH] |Mouth Neoplasms/*metabolism [MESH]Lewisy promotes migration of oral cancer cells by glycosylation of epi(epmc).pdf DeepDyve Pubget Overpricing