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10.1371/journal.pone.0121968 http://scihub22266oqcxt.onion/10.1371/journal.pone.0121968 C4370648!4370648 !25799045     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25799045 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2015 ; 10 (3 ): e0121968 Nephropedia Template TP {{tp|p=25799045 |t=2015. Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8 |pdf=|usr=}}{{25799045 }} gab.com Text Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8 JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25799045 #FOAvip Previous studies have demonstrated that the cell surface receptor Slamf1 (CD150) is requisite for optimal NADPH-oxidase (Nox2) dependent reactive oxygen species (ROS) production by phagocytes in response to Gram- bacteria. By contrast, Slamf8 (CD353) is a negative regulator of ROS in response to Gram+ and Gram- bacteria. Employing in vivo migration after skin sensitization, induction of peritonitis, and repopulation of the small intestine demonstrates that in vivo migration of Slamf1-/- dendritic cells and macrophages is reduced, as compared to wt mice. By contrast, in vivo migration of Slamf8-/- dendritic cells, macrophages and neutrophils is accelerated. These opposing effects of Slamf1 and Slamf8 are cell-intrinsic as judged by in vitro migration in transwell chambers in response to CCL19, CCL21 or CSF-1. Importantly, inhibiting ROS production of Slamf8-/- macrophages by diphenyleneiodonium chloride blocks this in vitro migration. We conclude that Slamf1 and Slamf8 govern ROS-dependent innate immune responses of myeloid cells, thus modulating migration of these cells during inflammation in an opposing manner. Twit Text FOAVip Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8 ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25799045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25799045 #FOAvip English Wikipedia <ref>{{Cite pmid|25799045 }}</ref> Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8 #MMPMID25799045 Wang G ; van Driel BJ ; Liao G ; O'Keeffe MS ; Halibozek PJ ; Flipse J ; Yigit B ; Azcutia V ; Luscinskas FW ; Wang N ; Terhorst C PLoS One 2015[]; 10 (3 ): e0121968 PMID25799045 show ga Previous studies have demonstrated that the cell surface receptor Slamf1 (CD150) is requisite for optimal NADPH-oxidase (Nox2) dependent reactive oxygen species (ROS) production by phagocytes in response to Gram- bacteria. By contrast, Slamf8 (CD353) is a negative regulator of ROS in response to Gram+ and Gram- bacteria. Employing in vivo migration after skin sensitization, induction of peritonitis, and repopulation of the small intestine demonstrates that in vivo migration of Slamf1-/- dendritic cells and macrophages is reduced, as compared to wt mice. By contrast, in vivo migration of Slamf8-/- dendritic cells, macrophages and neutrophils is accelerated. These opposing effects of Slamf1 and Slamf8 are cell-intrinsic as judged by in vitro migration in transwell chambers in response to CCL19, CCL21 or CSF-1. Importantly, inhibiting ROS production of Slamf8-/- macrophages by diphenyleneiodonium chloride blocks this in vitro migration. We conclude that Slamf1 and Slamf8 govern ROS-dependent innate immune responses of myeloid cells, thus modulating migration of these cells during inflammation in an opposing manner. |Animals [MESH] |Antigens, CD/genetics/metabolism/*physiology [MESH] |Cell Movement/genetics/physiology [MESH] |Chemotaxis/drug effects [MESH] |Dendritic Cells/cytology/metabolism [MESH] |Macrophages/cytology/metabolism [MESH] |Membrane Proteins [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Myeloid Cells/cytology/*metabolism [MESH] |Neutrophils/cytology/metabolism [MESH] |Peritonitis/metabolism/pathology [MESH] |Reactive Oxygen Species/metabolism [MESH] |Receptors, Cell Surface/genetics/metabolism/*physiology [MESH]Migration of myeloid cells during inflammation is differentially regul(epmc).pdf DeepDyve Pubget Overpricing