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10.1371/journal.pone.0121747 http://scihub22266oqcxt.onion/10.1371/journal.pone.0121747 C4370635!4370635 !25799492     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25799492 &cmd=llinks): Failed to open stream: HTTP request failed! 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ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-actin rosettes in breast cancer cells in response to epidermal growth factor |pdf=|usr=}}{{25799492 }} gab.com Text ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-actin rosettes in breast cancer cells in response to epidermal growth factor JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25799492 #FOAvip Coordination between actin cytoskeleton assembly and localized polarization of intracellular trafficking routes is crucial for cancer cell migration. ARF6 has been implicated in the endocytic recycling of surface receptors and membrane components and in actin cytoskeleton remodeling. Here we show that overexpression of an ARF6 fast-cycling mutant in MDA-MB-231 breast cancer-derived cells to mimick ARF6 hyperactivation observed in invasive breast tumors induced a striking rearrangement of the actin cytoskeleton at the ventral cell surface. This phenotype consisted in the formation of dynamic actin-based podosome rosette-like structures expanding outward as wave positive for F-actin and actin cytoskeleton regulatory components including cortactin, Arp2/3 and SCAR/WAVE complexes and upstream Rac1 regulator. Ventral rosette-like structures were similarly induced in MDA-MB-231 cells in response to epidermal growth factor (EGF) stimulation and to Rac1 hyperactivation. In addition, interference with ARF6 expression attenuated activation and plasma membrane targeting of Rac1 in response to EGF treatment. Our data suggest a role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration. Twit Text FOAVip ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-actin rosettes in breast cancer cells in response to epidermal growth factor ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25799492 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25799492 #FOAvip English Wikipedia <ref>{{Cite pmid|25799492 }}</ref> ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-actin rosettes in breast cancer cells in response to epidermal growth factor #MMPMID25799492 Marchesin V ; Montagnac G ; Chavrier P PLoS One 2015[]; 10 (3 ): e0121747 PMID25799492 show ga Coordination between actin cytoskeleton assembly and localized polarization of intracellular trafficking routes is crucial for cancer cell migration. ARF6 has been implicated in the endocytic recycling of surface receptors and membrane components and in actin cytoskeleton remodeling. Here we show that overexpression of an ARF6 fast-cycling mutant in MDA-MB-231 breast cancer-derived cells to mimick ARF6 hyperactivation observed in invasive breast tumors induced a striking rearrangement of the actin cytoskeleton at the ventral cell surface. This phenotype consisted in the formation of dynamic actin-based podosome rosette-like structures expanding outward as wave positive for F-actin and actin cytoskeleton regulatory components including cortactin, Arp2/3 and SCAR/WAVE complexes and upstream Rac1 regulator. Ventral rosette-like structures were similarly induced in MDA-MB-231 cells in response to epidermal growth factor (EGF) stimulation and to Rac1 hyperactivation. In addition, interference with ARF6 expression attenuated activation and plasma membrane targeting of Rac1 in response to EGF treatment. Our data suggest a role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration. |ADP-Ribosylation Factor 6 [MESH] |ADP-Ribosylation Factors/deficiency/genetics/*metabolism [MESH] |Actin Cytoskeleton/drug effects/metabolism [MESH] |Actins/*metabolism [MESH] |Breast Neoplasms/*pathology [MESH] |Cell Line, Tumor [MESH] |Cell Membrane/drug effects/metabolism [MESH] |Cell Movement/drug effects [MESH] |Epidermal Growth Factor/*pharmacology [MESH] |ErbB Receptors/metabolism [MESH] |Gene Silencing [MESH] |Humans [MESH] |RNA, Small Interfering/genetics [MESH] |Signal Transduction/drug effects [MESH] |Up-Regulation/drug effects [MESH] |Wiskott-Aldrich Syndrome Protein Family/*metabolism [MESH]ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-actin(epmc).pdf DeepDyve Pubget Overpricing