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10.1016/j.bbalip.2014.10.002 http://scihub22266oqcxt.onion/10.1016/j.bbalip.2014.10.002 C4370320!4370320!25316652     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2015 ; 1851 (4): 308-30 Nephropedia Template TP {{tp|p=25316652|t=2015. Mammalian lipoxygenases and their biological relevance |pdf=|usr=}}{{25316652}} gab.com Text Mammalian lipoxygenases and their biological relevance JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=25316652 #FOAvip Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which have been implicated in cell proliferation and differentiation but also in the pathogenesis of various diseases with major public health relevance. As other fatty acid dioxygenases LOX oxidize polyunsaturated fatty acids to their corresponding hydroperoxy derivatives, which are further transformed to bioactive lipid mediators (eicosanoids and related substances). On the other hand, lipoxygenases are key players in regulation of the cellular redox homeostasis, which is an important element in gene expression regulation. Although the first mammalian lipoxygenases were discovered 40 years ago and although the enzymes have been well characterized with respect to their structural and functional properties the biological roles of the different lipoxygenase isoforms are not completely understood. This review is aimed at summarizing the current knowledge on the physiological roles of different mammalian LOX-isoforms and their patho-physiological function in inflammatory, metabolic, hyperproliferative, neurodegenerative and infectious disorders. Twit Text FOAVip Mammalian lipoxygenases and their biological relevance ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=25316652 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25316652 #FOAvip English Wikipedia <ref>{{Cite pmid|25316652}}</ref> Mammalian lipoxygenases and their biological relevance #MMPMID25316652 Kuhn H; Banthiya S; van Leyen K Biochim Biophys Acta 2015[Apr]; 1851 (4): 308-30 PMID25316652show ga Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which have been implicated in cell proliferation and differentiation but also in the pathogenesis of various diseases with major public health relevance. As other fatty acid dioxygenases LOX oxidize polyunsaturated fatty acids to their corresponding hydroperoxy derivatives, which are further transformed to bioactive lipid mediators (eicosanoids and related substances). On the other hand, lipoxygenases are key players in regulation of the cellular redox homeostasis, which is an important element in gene expression regulation. Although the first mammalian lipoxygenases were discovered 40 years ago and although the enzymes have been well characterized with respect to their structural and functional properties the biological roles of the different lipoxygenase isoforms are not completely understood. This review is aimed at summarizing the current knowledge on the physiological roles of different mammalian LOX-isoforms and their patho-physiological function in inflammatory, metabolic, hyperproliferative, neurodegenerative and infectious disorders. äMammalian lipoxygenases and their biological relevance (epmc).pdf DeepDyve Pubget Overpricing