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10.1126/scisignal.2005816

http://scihub22266oqcxt.onion/10.1126/scisignal.2005816
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C4369380!4369380!25292212
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suck abstract from ncbi


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pmid25292212      Sci+Signal 2014 ; 7 (346): pe24
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  • Distinct Integrin-Dependent Signals Define Requirements for Lytic Granule Convergence and Polarization in Natural Killer Cells #MMPMID25292212
  • Hsu HT; Orange JS
  • Sci Signal 2014[Oct]; 7 (346): pe24 PMID25292212show ga
  • Lytic granules in natural killer (NK) cells represent a dangerous cargo that is targeted for secretion to destroy diseased cells. The appropriate management of these organelles enables the mounting of a precise and valuable host defense. The process of NK cell adhesion to a target cell through engagement of the integrin LFA-1 (lymphocyte function?associated antigen 1) promotes lytic granule organization through complex cellular mechanics and a signaling pathway characterized by Zhang et al. in this issue of Science Signaling. A limited, partially overlapping set of signaling molecules can be distinguished for their ability to promote the convergence of NK cell lytic granules on the microtubule organizing center and their polarization as they progress en masse toward the interface with a target cell.
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