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10.1111/bph.12675 http://scihub22266oqcxt.onion/10.1111/bph.12675 C4369256!4369256!24601995     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2015 ; 172 (6): 1455-67 Nephropedia Template TP {{tp|p=24601995|t=2015. New insights into male (in)fertility: the importance of NO |pdf=|usr=}}{{24601995}} gab.com Text New insights into male (in)fertility: the importance of NO JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24601995 #FOAvip Infertility is a global problem that is on the rise, especially during the last decade. Currently, infertility affects approximately 10?15% of the population worldwide. The frequency and origin of different forms of infertility varies. It has been shown that reactive oxygen and nitrogen species (ROS and RNS) are involved in the aetiology of infertility, especially male infertility. Various strategies have been designed to remove or decrease the production of ROS and RNS in spermatozoa, in particular during in vitro fertilization. However, in recent years it has been shown that spermatozoa naturally produce a variety of ROS/RNS, including superoxide anion radical (O2??), hydrogen peroxide and NO. These reactive species, in particular NO, are essential in regulating sperm capacitation and the acrosome reaction, two processes that need to be acquired by sperm in order to achieve fertilization potential. In addition, it has recently been shown that mitochondrial function is positively correlated with human sperm fertilization potential and quality and that NO and NO precursors increase sperm motility by increasing energy production in mitochondria. We will review the new link between sperm NO-driven redox regulation and infertility herein. A special emphasis will be placed on the potential implementation of new redox-active substances that modulate the content of NO in spermatozoa to increase fertility and promote conception.Linked Articles: This article is part of a themed section on Pharmacology of the Gasotransmitters. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-6 Twit Text FOAVip New insights into male (in)fertility: the importance of NO ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24601995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24601995 #FOAvip English Wikipedia <ref>{{Cite pmid|24601995}}</ref> New insights into male (in)fertility: the importance of NO #MMPMID24601995 Buzadzic B; Vucetic M; Jankovic A; Stancic A; Korac A; Korac B; Otasevic V Br J Pharmacol 2015[Mar]; 172 (6): 1455-67 PMID24601995show ga Infertility is a global problem that is on the rise, especially during the last decade. Currently, infertility affects approximately 10?15% of the population worldwide. The frequency and origin of different forms of infertility varies. It has been shown that reactive oxygen and nitrogen species (ROS and RNS) are involved in the aetiology of infertility, especially male infertility. Various strategies have been designed to remove or decrease the production of ROS and RNS in spermatozoa, in particular during in vitro fertilization. However, in recent years it has been shown that spermatozoa naturally produce a variety of ROS/RNS, including superoxide anion radical (O2??), hydrogen peroxide and NO. These reactive species, in particular NO, are essential in regulating sperm capacitation and the acrosome reaction, two processes that need to be acquired by sperm in order to achieve fertilization potential. In addition, it has recently been shown that mitochondrial function is positively correlated with human sperm fertilization potential and quality and that NO and NO precursors increase sperm motility by increasing energy production in mitochondria. We will review the new link between sperm NO-driven redox regulation and infertility herein. A special emphasis will be placed on the potential implementation of new redox-active substances that modulate the content of NO in spermatozoa to increase fertility and promote conception.Linked Articles: This article is part of a themed section on Pharmacology of the Gasotransmitters. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-6 äNew insights into male (in)fertility: the importance of NO (epmc).pdf DeepDyve Pubget Overpricing