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10.1055/s-0034-1387930

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C4369158!4369158!25241107
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suck abstract from ncbi


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pmid25241107      Am+J+Perinatol 2015 ; 32 (4): 387-92
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  • The effect of magnesium sulfate administration for neuroprotection on latency in women with preterm premature rupture of membranes #MMPMID25241107
  • Horton AL; Lai Y; Rouse DJ; Spong CY; Leveno KJ; Varner MW; Mercer BM; Iams JD; Wapner RJ; Sorokin Y; Thorp JM; Ramin SM; Malone FD; O'Sullivan MJ; Hankins GDV; Caritis SN
  • Am J Perinatol 2015[Mar]; 32 (4): 387-92 PMID25241107show ga
  • Objective: To evaluate whether magnesium sulfate administration for neuroprotection prolongs latency in women with preterm premature rupture of membranes between 24 and 31 6/7 weeks' gestation. Study Design: This is a secondary analysis of a randomized controlled trial of magnesium sulfate for prevention of cerebral palsy. Gravid women with a singleton pregnancy between 24 and 31 6/7 weeks' gestation with preterm premature rupture of membranes (pPROM) without evidence of labor were randomized to receive magnesium sulfate, administered intravenously as a 6-g bolus followed by a constant infusion of 2 g per hour up to 12 hours, or placebo. Maternal outcomes for this analysis were delivery in less than 48 hours and in less than 7 days from randomization. Neonatal outcomes included a composite of respiratory distress, interventricular hemorrhage grades 3 or 4, periventricular leukomalacia, sepsis, necrotizing enterocolitis, retinopathy of prematurity, or death. Results: A total of 1259 women were included. The rate of delivery < 48 hours was not different in the magnesium sulfate and the placebo groups (22.2% and 20.7%, p=0.51). Delivery < 7 days was similar between groups (55.4% and 51.4%, p=0.16). Median latency was also similar between groups (median [interquartile range] 6.0 days [2.4?13.8] and 6.6 days [2.4?15.1], p =0.29). Composite neonatal outcomes did not differ between groups. Conclusion: Magnesium sulfate administration given for neuroprotection in women with a singleton gestation with preterm premature rupture of membranes and without labor before 32 weeks does not impact latency.
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