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10.1136/bcr-2014-208215

http://scihub22266oqcxt.onion/10.1136/bcr-2014-208215
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C4369033!4369033!25743864
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suck abstract from ncbi


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pmid25743864      BMJ+Case+Rep 2015 ; 2015 (ä): ä
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  • Neuropsychiatric systemic lupus erythematosus: a diagnostic challenge #MMPMID25743864
  • Sommerlad A; Duncan J; Lunn MPT; Foong J
  • BMJ Case Rep 2015[]; 2015 (ä): ä PMID25743864show ga
  • A 58-year-old woman presented to neuropsychiatric services with increased frequency of confusional episodes and intermittent psychotic symptoms. She had a 19-year history of atypical epileptic seizures and cognitive decline. Detailed review of history and clinical investigations revealed that she had accumulated sufficient features to meet diagnostic criteria for systemic lupus erythematosus (SLE). She had previously had lymphopenia and a malar rash; she had positive antinuclear, anti-Ro (anti-Sjögren's-syndrome-related antigen A) and anti-SM (anti-Smith Antibody) antibodies, and elevated erythrocyte sedimentation rate. The seizures, cognitive impairment and psychosis were attributable to neuropsychiatric SLE. Treatment with immune-modulating therapy, cyclophosphamide, resulted in significant improvement in subjective and objective clinical presentation. Neuropsychiatric SLE should be considered a potential differential diagnosis for patients presenting with seizures, psychotic symptoms or cognitive decline. A detailed clinical evaluation with review of the medical history and appropriate laboratory analyses allows this diagnosis to be made, and appropriate treatment to be initiated.
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