Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25612894
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Erotic stimulus processing under amisulpride and reboxetine: a placebo-controlled
fMRI study in healthy subjects
#MMPMID25612894
Graf H
; Wiegers M
; Metzger CD
; Walter M
; Grön G
; Abler B
Int J Neuropsychopharmacol
2014[Oct]; 18
(2
): ? PMID25612894
show ga
BACKGROUND: Impaired sexual function is increasingly recognized as a side effect
of psychopharmacological treatment. However, underlying mechanisms of action of
the different drugs on sexual processing are still to be explored. Using
functional magnetic resonance imaging, we previously investigated effects of
serotonergic (paroxetine) and dopaminergic (bupropion) antidepressants on sexual
functioning (Abler et al., 2011). Here, we studied the impact of noradrenergic
and antidopaminergic medication on neural correlates of visual sexual stimulation
in a new sample of subjects. METHODS: Nineteen healthy heterosexual males (mean
age 24 years, SD 3.1) under subchronic intake (7 days) of the noradrenergic agent
reboxetine (4 mg/d), the antidopaminergic agent amisulpride (200mg/d), and
placebo were included and studied with functional magnetic resonance imaging
within a randomized, double-blind, placebo-controlled, within-subjects design
during an established erotic video-clip task. Subjective sexual functioning was
assessed using the Massachusetts General Hospital-Sexual Functioning
Questionnaire. RESULTS: Relative to placebo, subjective sexual functioning was
attenuated under reboxetine along with diminished neural activations within the
caudate nucleus. Altered neural activations correlated with decreased sexual
interest. Under amisulpride, neural activations and subjective sexual functioning
remained unchanged. CONCLUSIONS: In line with previous interpretations of the
role of the caudate nucleus in the context of primary reward processing,
attenuated caudate activation may reflect detrimental effects on motivational
aspects of erotic stimulus processing under noradrenergic agents.
free
free
free
