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10.1093/eurheartj/ehu484 http://scihub22266oqcxt.onion/10.1093/eurheartj/ehu484 C4368857!4368857 !25670819     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25670819 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+Heart+J 2015 ; 36 (12 ): 715-23 Nephropedia Template TP {{tp|p=25670819 |t=2015. Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies |pdf=|usr=}}{{25670819 }} gab.com Text Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies JO: Eur Heart J http://www.kidney.de/pget.php?&tw=1&pmid=25670819 #FOAvip The short- and long-term morbidity and mortality in acute heart failure is still unacceptably high. There is an unmet need for new therapy options with new drugs with a new mode of action. One of the drugs currently in clinical testing in Phase III is ularitide, which is the chemically synthesized form of the human natriuretic peptide urodilatin. Urodilatin is produced in humans by differential processing of pro-atrial natriuretic peptide in distal renal tubule cells. Physiologically, urodilatin appears to be the natriuretic peptide involved in sodium homeostasis. Ularitide exerts its pharmacological actions such as vasodilation, diuresis, and natriuresis through the natriuretic peptide receptor/particulate guanylate cyclase/cyclic guanosine monophosphate pathway. In animal models of heart failure as well as Phase I and II clinical studies in heart failure patients, ularitide demonstrated beneficial effects such as symptom relief and vasodilation, while still preserving renal function. Subsequently, the pivotal acute decompensated heart failure (ADHF) Phase III study, called TRUE-AHF, was started with the objectives to evaluate the effects of ularitide infusion on the clinical status and cardiovascular mortality of patients with ADHF compared with placebo. This review summarizes preclinical and clinical data supporting the potential use of ularitide in the treatment of ADHF. Twit Text FOAVip Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies ????Eur Heart J http://www.kidney.de/pget.php?&tw=1&pmid=25670819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25670819 #FOAvip English Wikipedia <ref>{{Cite pmid|25670819 }}</ref> Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies #MMPMID25670819 Anker SD ; Ponikowski P ; Mitrovic V ; Peacock WF ; Filippatos G Eur Heart J 2015[Mar]; 36 (12 ): 715-23 PMID25670819 show ga The short- and long-term morbidity and mortality in acute heart failure is still unacceptably high. There is an unmet need for new therapy options with new drugs with a new mode of action. One of the drugs currently in clinical testing in Phase III is ularitide, which is the chemically synthesized form of the human natriuretic peptide urodilatin. Urodilatin is produced in humans by differential processing of pro-atrial natriuretic peptide in distal renal tubule cells. Physiologically, urodilatin appears to be the natriuretic peptide involved in sodium homeostasis. Ularitide exerts its pharmacological actions such as vasodilation, diuresis, and natriuresis through the natriuretic peptide receptor/particulate guanylate cyclase/cyclic guanosine monophosphate pathway. In animal models of heart failure as well as Phase I and II clinical studies in heart failure patients, ularitide demonstrated beneficial effects such as symptom relief and vasodilation, while still preserving renal function. Subsequently, the pivotal acute decompensated heart failure (ADHF) Phase III study, called TRUE-AHF, was started with the objectives to evaluate the effects of ularitide infusion on the clinical status and cardiovascular mortality of patients with ADHF compared with placebo. This review summarizes preclinical and clinical data supporting the potential use of ularitide in the treatment of ADHF. |Acute Disease [MESH] |Animals [MESH] |Atrial Natriuretic Factor/pharmacology/*therapeutic use [MESH] |Clinical Trials as Topic [MESH] |Disease Models, Animal [MESH] |Diuretics/pharmacology/*therapeutic use [MESH] |Female [MESH] |Heart Failure/*drug therapy [MESH] |Humans [MESH] |Male [MESH] |Peptide Fragments/pharmacology/therapeutic use [MESH] |Rats, Wistar [MESH]Ularitide for the treatment of acute decompensated heart failure: from(epmc).pdf DeepDyve Pubget Overpricing