Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/imm.12417 http://scihub22266oqcxt.onion/10.1111/imm.12417 C4368171!4368171 !25346485     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25346485 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Immunology 2015 ; 144 (4 ): 649-60 Nephropedia Template TP {{tp|p=25346485 |t=2015. The presence of interleukin-27 during monocyte-derived dendritic cell differentiation promotes improved antigen processing and stimulation of T cells |pdf=|usr=}}{{25346485 }} gab.com Text The presence of interleukin-27 during monocyte-derived dendritic cell differentiation promotes improved antigen processing and stimulation of T cells JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=25346485 #FOAvip Dendritic cells (DCs) are potent antigen-presenting cells necessary to establish effective adaptive immune responses. The cytokine environment that exists at the time of DC differentiation may be an important but often ignored determinant in the phenotypic and functional properties of DCs. Interleukin-27 (IL-27) is a unique cytokine that has both inflammatory and immune suppressive activities. Although it can both promote and oppose activity of different T-cell subsets, mostly anti-inflammatory activity has been described toward macrophages and DCs. However, the specific effect of IL-27 during DC differentiation and how that may change the nature of the antigen-presenting cell has not been investigated. In this report, we show that IL-27 treatment during monocyte-derived DC differentiation enhanced the ability to process antigens and stimulate T-cell activity. DCs differentiated in the presence of IL-27 showed enhanced acidification of latex bead-containing phagosomes that was consistent with elevated expression of vacuolar-ATPases. This resulted in inhibition of intracellular growth of Staphylococcus aureus. In addition, the levels of MHC class II surface expression were higher in DCs differentiated in the presence of IL-27. Production of IL-12 was also significantly increased during S. aureus infection of IL-27-differentiated DCs. The net effect of these activities was enhanced CD4(+) T-cell proliferation and T helper type 1 cytokine production. These findings are important to a wide number of immunological contexts and should be considered in the development of future vaccines. Twit Text FOAVip The presence of interleukin-27 during monocyte-derived dendritic cell differentiation promotes improved antigen processing and stimulation of T cells ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=25346485 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25346485 #FOAvip English Wikipedia <ref>{{Cite pmid|25346485 }}</ref> The presence of interleukin-27 during monocyte-derived dendritic cell differentiation promotes improved antigen processing and stimulation of T cells #MMPMID25346485 Jung JY ; Roberts LL ; Robinson CM Immunology 2015[Apr]; 144 (4 ): 649-60 PMID25346485 show ga Dendritic cells (DCs) are potent antigen-presenting cells necessary to establish effective adaptive immune responses. The cytokine environment that exists at the time of DC differentiation may be an important but often ignored determinant in the phenotypic and functional properties of DCs. Interleukin-27 (IL-27) is a unique cytokine that has both inflammatory and immune suppressive activities. Although it can both promote and oppose activity of different T-cell subsets, mostly anti-inflammatory activity has been described toward macrophages and DCs. However, the specific effect of IL-27 during DC differentiation and how that may change the nature of the antigen-presenting cell has not been investigated. In this report, we show that IL-27 treatment during monocyte-derived DC differentiation enhanced the ability to process antigens and stimulate T-cell activity. DCs differentiated in the presence of IL-27 showed enhanced acidification of latex bead-containing phagosomes that was consistent with elevated expression of vacuolar-ATPases. This resulted in inhibition of intracellular growth of Staphylococcus aureus. In addition, the levels of MHC class II surface expression were higher in DCs differentiated in the presence of IL-27. Production of IL-12 was also significantly increased during S. aureus infection of IL-27-differentiated DCs. The net effect of these activities was enhanced CD4(+) T-cell proliferation and T helper type 1 cytokine production. These findings are important to a wide number of immunological contexts and should be considered in the development of future vaccines. |Antigen Presentation/*drug effects [MESH] |CD4-Positive T-Lymphocytes/*drug effects/immunology/metabolism [MESH] |Cell Differentiation/*drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Cells, Cultured [MESH] |Coculture Techniques [MESH] |Dendritic Cells/*drug effects/immunology/metabolism/microbiology [MESH] |Histocompatibility Antigens Class II/immunology/metabolism [MESH] |Humans [MESH] |Hydrogen-Ion Concentration [MESH] |Interleukin-12/immunology/metabolism [MESH] |Interleukin-27/*pharmacology [MESH] |Lymphocyte Activation/*drug effects [MESH] |Monocytes/*drug effects/immunology/metabolism [MESH] |Phagosomes/drug effects/immunology/metabolism [MESH] |Signal Transduction [MESH] |Staphylococcus aureus/drug effects/growth & development/immunology [MESH] |Th1 Cells/drug effects/immunology/metabolism [MESH]The presence of interleukin-27 during monocyte-derived dendritic cell (epmc).pdf DeepDyve Pubget Overpricing