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Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Blood 2015 ; 125 (12): 1976-85 Nephropedia Template TP
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Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar #MMPMID25587041
Aisiku O; Peters CG; De Ceunynck K; Ghosh CC; Dilks JR; Fustolo-Gunnink SF; Huang M; Dockendorff C; Parikh SM; Flaumenhaft R
Blood 2015[Mar]; 125 (12): 1976-85 PMID25587041show ga
Parmodulins are a new class of PAR1 inhibitors that target the cytosolic face of PAR1 to block signaling through G?q, but not G?12/13.Unlike vorapaxar, which causes endothelial injury, parmodulins selectively block proinflammatory, but not cytoprotective, signaling.