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10.1182/blood-2014-09-599910

http://scihub22266oqcxt.onion/10.1182/blood-2014-09-599910
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C4366627!4366627!25587041
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suck abstract from ncbi


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pmid25587041      Blood 2015 ; 125 (12): 1976-85
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  • Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar #MMPMID25587041
  • Aisiku O; Peters CG; De Ceunynck K; Ghosh CC; Dilks JR; Fustolo-Gunnink SF; Huang M; Dockendorff C; Parikh SM; Flaumenhaft R
  • Blood 2015[Mar]; 125 (12): 1976-85 PMID25587041show ga
  • Parmodulins are a new class of PAR1 inhibitors that target the cytosolic face of PAR1 to block signaling through G?q, but not G?12/13.Unlike vorapaxar, which causes endothelial injury, parmodulins selectively block proinflammatory, but not cytoprotective, signaling.
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