Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.cell.2014.02.052 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.02.052 C4365996!4365996!24726433     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 157 (3): 611-23 Nephropedia Template TP {{tp|p=24726433|t=2014. Water Permeation Drives Tumor Cell Migration in Confined Microenvironments |pdf=|usr=}}{{24726433}} gab.com Text Water Permeation Drives Tumor Cell Migration in Confined Microenvironments JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=24726433 #FOAvip Cell migration is a critical process for diverse (patho) physiological phenomena. Intriguingly, cell migration through physically confined spaces can persist even when typical hallmarks of 2D planar migration, such as actin polymerization and myosin II-mediated contractility, are inhibited. Here, we present an integrated experimental and theoretical approach (?Osmotic Engine Model?) and demonstrate that directed water permeation is a major mechanism of cell migration in confined microenvironments. Using microfluidic and imaging techniques along with mathematical modeling, we show that tumor cells confined in a narrow channel establish a polarized distribution of Na+/H+ pumps and aquaporins in the cell membrane, which creates a net inflow of water and ions at the cell leading edge and a net outflow of water and ions at the trailing edge, leading to net cell displacement. Collectively, this study presents an alternate mechanism of cell migration in confinement that depends on cell-volume regulation via water permeation. Twit Text FOAVip Water Permeation Drives Tumor Cell Migration in Confined Microenvironments ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=24726433 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24726433 #FOAvip English Wikipedia <ref>{{Cite pmid|24726433}}</ref> Water Permeation Drives Tumor Cell Migration in Confined Microenvironments #MMPMID24726433 Stroka KM; Jiang H; Chen SH; Tong Z; Wirtz D; Sun SX; Konstantopoulos K Cell 2014[Apr]; 157 (3): 611-23 PMID24726433show ga Cell migration is a critical process for diverse (patho) physiological phenomena. Intriguingly, cell migration through physically confined spaces can persist even when typical hallmarks of 2D planar migration, such as actin polymerization and myosin II-mediated contractility, are inhibited. Here, we present an integrated experimental and theoretical approach (?Osmotic Engine Model?) and demonstrate that directed water permeation is a major mechanism of cell migration in confined microenvironments. Using microfluidic and imaging techniques along with mathematical modeling, we show that tumor cells confined in a narrow channel establish a polarized distribution of Na+/H+ pumps and aquaporins in the cell membrane, which creates a net inflow of water and ions at the cell leading edge and a net outflow of water and ions at the trailing edge, leading to net cell displacement. Collectively, this study presents an alternate mechanism of cell migration in confinement that depends on cell-volume regulation via water permeation. äWater Permeation Drives Tumor Cell Migration in Confined Microenvironm(epmc).pdf DeepDyve Pubget Overpricing