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10.3389/fnins.2015.00083 http://scihub22266oqcxt.onion/10.3389/fnins.2015.00083 C4365721!4365721!25852459     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Neurosci 2015 ; 9 (ä): ä Nephropedia Template TP {{tp|p=25852459|t=2015. Local modulation of steroid action: rapid control of enzymatic activity |pdf=|usr=}}{{25852459}} gab.com Text Local modulation of steroid action: rapid control of enzymatic activity JO: Front Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25852459 #FOAvip Estrogens can induce rapid, short-lived physiological and behavioral responses, in addition to their slow, but long-term, effects at the transcriptional level. To be functionally relevant, these effects should be associated with rapid modulations of estrogens concentrations. 17?-estradiol is synthesized by the enzyme aromatase, using testosterone as a substrate, but can also be degraded into catechol-estrogens via hydroxylation by the same enzyme, leading to an increase or decrease in estrogens concentration, respectively. The first evidence that aromatase activity (AA) can be rapidly modulated came from experiments performed in Japanese quail hypothalamus homogenates. This rapid modulation is triggered by calcium-dependent phosphorylations and was confirmed in other tissues and species. The mechanisms controlling the phosphorylation status, the targeted amino acid residues and the reversibility seem to vary depending of the tissues and is discussed in this review. We currently do not know whether the phosphorylation of the same amino acid affects both aromatase and/or hydroxylase activities or whether these residues are different. These processes provide a new general mechanism by which local estrogen concentration can be rapidly altered in the brain and other tissues. Twit Text FOAVip Local modulation of steroid action: rapid control of enzymatic activity ????Front Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25852459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25852459 #FOAvip English Wikipedia <ref>{{Cite pmid|25852459}}</ref> Local modulation of steroid action: rapid control of enzymatic activity #MMPMID25852459 Charlier TD; Cornil CA; Patte-Mensah C; Meyer L; Mensah-Nyagan AG; Balthazart J Front Neurosci 2015[]; 9 (ä): ä PMID25852459show ga Estrogens can induce rapid, short-lived physiological and behavioral responses, in addition to their slow, but long-term, effects at the transcriptional level. To be functionally relevant, these effects should be associated with rapid modulations of estrogens concentrations. 17?-estradiol is synthesized by the enzyme aromatase, using testosterone as a substrate, but can also be degraded into catechol-estrogens via hydroxylation by the same enzyme, leading to an increase or decrease in estrogens concentration, respectively. The first evidence that aromatase activity (AA) can be rapidly modulated came from experiments performed in Japanese quail hypothalamus homogenates. This rapid modulation is triggered by calcium-dependent phosphorylations and was confirmed in other tissues and species. The mechanisms controlling the phosphorylation status, the targeted amino acid residues and the reversibility seem to vary depending of the tissues and is discussed in this review. We currently do not know whether the phosphorylation of the same amino acid affects both aromatase and/or hydroxylase activities or whether these residues are different. These processes provide a new general mechanism by which local estrogen concentration can be rapidly altered in the brain and other tissues. äLocal modulation of steroid action: rapid control of enzymatic activit(epmc).pdf DeepDyve Pubget Overpricing