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10.1155/2015/167283 http://scihub22266oqcxt.onion/10.1155/2015/167283 C4365328!4365328!25834831     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Diabetes+Res 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=25834831|t=2015. Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes |pdf=|usr=}}{{25834831}} gab.com Text Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes JO: J Diabetes Res http://www.kidney.de/pget.php?&tw=1&pmid=25834831 #FOAvip Cell microenvironment has a critical role determining cell fate and modulating cell responses to injuries. Hyaluronan (HA) is a ubiquitous extracellular matrix glycosaminoglycan that can be considered a signaling molecule. In fact, interacting with several cell surface receptors can deeply shape cell behavior. In vascular biology, HA triggers smooth muscle cells (SMCs) dedifferentiation which contributes to vessel wall thickening. Furthermore, HA is able to modulate inflammation by altering the adhesive properties of endothelial cells. In hyperglycemic conditions, HA accumulates in vessels and can contribute to the diabetic complications at micro- and macrovasculature. Due to the pivotal role in favoring atherogenesis and neointima formation after injuries, HA could be a new target for cardiovascular pathologies. This review will focus on the recent findings regarding the regulation of HA synthesis in human vascular SMCs. In particular, the effects of the intracellular HA substrates availability, adenosine monophosphate-activated protein kinase (AMPK), and protein O-GlcNAcylation on the main HA synthetic enzyme (i.e., HAS2) will be discussed. Twit Text FOAVip Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes ????J Diabetes Res http://www.kidney.de/pget.php?&tw=1&pmid=25834831 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25834831 #FOAvip English Wikipedia <ref>{{Cite pmid|25834831}}</ref> Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes #MMPMID25834831 Moretto P; Karousou E; Viola M; Caon I; D'Angelo ML; De Luca G; Passi A; Vigetti D J Diabetes Res 2015[]; 2015 (ä): ä PMID25834831show ga Cell microenvironment has a critical role determining cell fate and modulating cell responses to injuries. Hyaluronan (HA) is a ubiquitous extracellular matrix glycosaminoglycan that can be considered a signaling molecule. In fact, interacting with several cell surface receptors can deeply shape cell behavior. In vascular biology, HA triggers smooth muscle cells (SMCs) dedifferentiation which contributes to vessel wall thickening. Furthermore, HA is able to modulate inflammation by altering the adhesive properties of endothelial cells. In hyperglycemic conditions, HA accumulates in vessels and can contribute to the diabetic complications at micro- and macrovasculature. Due to the pivotal role in favoring atherogenesis and neointima formation after injuries, HA could be a new target for cardiovascular pathologies. This review will focus on the recent findings regarding the regulation of HA synthesis in human vascular SMCs. In particular, the effects of the intracellular HA substrates availability, adenosine monophosphate-activated protein kinase (AMPK), and protein O-GlcNAcylation on the main HA synthetic enzyme (i.e., HAS2) will be discussed. äRegulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes (epmc).pdf DeepDyve Pubget Overpricing