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10.1016/j.immuni.2015.02.002 http://scihub22266oqcxt.onion/10.1016/j.immuni.2015.02.002 C4365295!4365295!25786173     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2015 ; 42 (3): 406-17 Nephropedia Template TP {{tp|p=25786173|t=2015. Mitochondria in the regulation of innate and adaptive immunity |pdf=|usr=}}{{25786173}} gab.com Text Mitochondria in the regulation of innate and adaptive immunity JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25786173 #FOAvip Mitochondria are well appreciated for their role as biosynthetic and bioenergetic organelles. In the past two decades, mitochondria have emerged as signaling organelles that contribute critical decisions about cell proliferation, death and differentiation. Mitochondria not only sustain immune cell phenotypes but also are necessary for establishing immune cell phenotype and their function. Mitochondria can rapidly switch from primarily being catabolic organelles generating ATP to anabolic organelles that generate both ATP and building blocks for macromolecule synthesis. This enables them to fulfill appropriate metabolic demands of different immune cells. Mitochondria have multiple mechanisms that allow them to activate signaling pathways in the cytosol including altering in AMP/ATP ratio, the release of ROS and TCA cycle metabolites, as well as the localization of immune regulatory proteins on the outer mitochondrial membrane. In this Review, we discuss the evidence and mechanisms that mitochondrial dependent signaling controls innate and adaptive immune responses. Twit Text FOAVip Mitochondria in the regulation of innate and adaptive immunity ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=25786173 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25786173 #FOAvip English Wikipedia <ref>{{Cite pmid|25786173}}</ref> Mitochondria in the regulation of innate and adaptive immunity #MMPMID25786173 Weinberg SE; Sena LA; Chandel NS Immunity 2015[Mar]; 42 (3): 406-17 PMID25786173show ga Mitochondria are well appreciated for their role as biosynthetic and bioenergetic organelles. In the past two decades, mitochondria have emerged as signaling organelles that contribute critical decisions about cell proliferation, death and differentiation. Mitochondria not only sustain immune cell phenotypes but also are necessary for establishing immune cell phenotype and their function. Mitochondria can rapidly switch from primarily being catabolic organelles generating ATP to anabolic organelles that generate both ATP and building blocks for macromolecule synthesis. This enables them to fulfill appropriate metabolic demands of different immune cells. Mitochondria have multiple mechanisms that allow them to activate signaling pathways in the cytosol including altering in AMP/ATP ratio, the release of ROS and TCA cycle metabolites, as well as the localization of immune regulatory proteins on the outer mitochondrial membrane. In this Review, we discuss the evidence and mechanisms that mitochondrial dependent signaling controls innate and adaptive immune responses. äMitochondria in the regulation of innate and adaptive immunity (epmc).pdf DeepDyve Pubget Overpricing