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10.15252/embr.201439333 http://scihub22266oqcxt.onion/10.15252/embr.201439333 C4364871!4364871!25643708     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2015 ; 16 (3): 321-31 Nephropedia Template TP {{tp|p=25643708|t=2015. Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism |pdf=|usr=}}{{25643708}} gab.com Text Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25643708 #FOAvip This study proposes that the transcription factor Zeb1 modulates epithelial cell adhesion by diverting glycosphingolipid metabolism. Zeb1 promotes expression of a-series glycosphingolipids via regulating expression of GM3 synthase (St3gal5), which mechanistically involves Zeb1 binding to the St3gal5 promoter as well as suppressing microRNA-mediated repression of St3gal5. Functionally, the repression of St3gal5 suffices to elevate intercellular adhesion and expression of distinct junction-associated proteins, reminiscent of knockdown of Zeb1. Conversely, overexpressing St3gal5 sensitizes cells towards TGF-?1-induced disruption of cell?cell interaction and partially antagonizes elevation of intercellular adhesion imposed by Zeb1 knockdown. These results highlight a direct connection of glycosphingolipid metabolism and epithelial cell adhesion via Zeb1. Twit Text FOAVip Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25643708 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25643708 #FOAvip English Wikipedia <ref>{{Cite pmid|25643708}}</ref> Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism #MMPMID25643708 Mathow D; Chessa F; Rabionet M; Kaden S; Jennemann R; Sandhoff R; Gröne HJ; Feuerborn A EMBO Rep 2015[Mar]; 16 (3): 321-31 PMID25643708show ga This study proposes that the transcription factor Zeb1 modulates epithelial cell adhesion by diverting glycosphingolipid metabolism. Zeb1 promotes expression of a-series glycosphingolipids via regulating expression of GM3 synthase (St3gal5), which mechanistically involves Zeb1 binding to the St3gal5 promoter as well as suppressing microRNA-mediated repression of St3gal5. Functionally, the repression of St3gal5 suffices to elevate intercellular adhesion and expression of distinct junction-associated proteins, reminiscent of knockdown of Zeb1. Conversely, overexpressing St3gal5 sensitizes cells towards TGF-?1-induced disruption of cell?cell interaction and partially antagonizes elevation of intercellular adhesion imposed by Zeb1 knockdown. These results highlight a direct connection of glycosphingolipid metabolism and epithelial cell adhesion via Zeb1. äZeb1 affects epithelial cell adhesion by diverting glycosphingolipid m(epmc).pdf DeepDyve Pubget Overpricing