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10.15252/embr.201439949 http://scihub22266oqcxt.onion/10.15252/embr.201439949 C4364868!4364868!25680965     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2015 ; 16 (3): 280-96 Nephropedia Template TP {{tp|p=25680965|t=2015. Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure |pdf=|usr=}}{{25680965}} gab.com Text Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25680965 #FOAvip A key goal of cancer therapeutics is to selectively target the genetic lesions that initiate and maintain cancer cell proliferation and survival. While most cancers harbor multiple oncogenic mutations, a wealth of preclinical and clinical data supports that many cancers are sensitive to inhibition of single oncogenes, a concept referred to as ?oncogene addiction?. Herein, we describe the clinical evidence supporting oncogene addiction and discuss common mechanistic themes emerging from the response and acquired resistance to oncogene-targeted therapies. Finally, we suggest several opportunities toward exploiting oncogene addiction to achieve curative cancer therapies. Twit Text FOAVip Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=25680965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25680965 #FOAvip English Wikipedia <ref>{{Cite pmid|25680965}}</ref> Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure #MMPMID25680965 Pagliarini R; Shao W; Sellers WR EMBO Rep 2015[Mar]; 16 (3): 280-96 PMID25680965show ga A key goal of cancer therapeutics is to selectively target the genetic lesions that initiate and maintain cancer cell proliferation and survival. While most cancers harbor multiple oncogenic mutations, a wealth of preclinical and clinical data supports that many cancers are sensitive to inhibition of single oncogenes, a concept referred to as ?oncogene addiction?. Herein, we describe the clinical evidence supporting oncogene addiction and discuss common mechanistic themes emerging from the response and acquired resistance to oncogene-targeted therapies. Finally, we suggest several opportunities toward exploiting oncogene addiction to achieve curative cancer therapies. äOncogene addiction: pathways of therapeutic response, resistance, and (epmc).pdf DeepDyve Pubget Overpricing